The genomic landscape of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21

Qingsong Gao,  Sarra L. Ryan,  Ilaria Iacobucci,  Pankaj S. Ghate,  Ruth E. Cranston,  Claire Schwab,  Abdelrahman H. Elsayed,  Lei Shi,  Stanley Pounds,  Shaohua Lei,  Pradyuamna Baviskar,  Deqing Pei,  Cheng Cheng,  Matthew Bashton,  Paul Sinclair,  David R. Bentley,  Mark T. Ross,  Zoya Kingsbury,  Terena James,  Kathryn G. Roberts,  Meenakshi Devidas,  Yiping Fan,  Wenan Chen,  Ti-Cheng Chang,  Gang Wu,  Andrew Carroll,  Nyla Heerema,  Virginia Valentine,  Marcus Valentine,  Wenjian Yang,  Jun J. Yang,  Anthony V. Moorman,  Christine J. Harrison,  Charles G. Mullighan.

Blood
Volume: 142, Issue: 8, Pages: 711-723.

Retinal pigment epithelium exhibits gene expression and phagocytic activity alterations when exposed to retinoblastoma chemotherapeutics

Rodrigo Cerna-Chavez,  Agata Rozanska,  Giulia Lodovica Poretti,  Nissim Benvenisty,  Manoj Parulekar,  Majlinda Lako.

Experimental Eye Research
Volume: 233, Pages: 109542.

The Clinicogenomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia

David O'Connor,  Jonas Demeulemeester,  Lucia Conde,  Amy Kirkwood,  Kent Fung,  Foteini Papaleonidopoulou,  Gianna Bloye,  Nadine Farah,  Sunniyat Rahman,  Jeremy Hancock,  Caroline Bateman,  Sarah Inglott,  Jon Mee,  Javier Herrero,  Peter Van Loo,  Anthony V. Moorman,  Ajay Vora,  Marc R. Mansour.

Journal of Clinical Oncology
Volume: 41, Issue: 19, Pages: 3545-3556.

The proteomic landscape of soft tissue sarcomas

Jessica Burns,  Christopher P. Wilding,  Lukas Krasny,  Xixuan Zhu,  Madhumeeta Chadha,  Yuen Bun Tam,  Hari Ps,  Aswanth H. Mahalingam,  Alexander T. J. Lee,  Amani Arthur,  Nafia Guljar,  Emma Perkins,  Valeriya Pankova,  Andrew Jenks,  Vanessa Djabatey,  Cornelia Szecsei,  Frank McCarthy,  Chanthirika Ragulan,  Martina Milighetti,  Theodoros I. Roumeliotis,  Stephen Crosier,  Martina Finetti,  Jyoti S. Choudhary,  Ian Judson,  Cyril Fisher,  Eugene F. Schuster,  Anguraj Sadanandam,  Tom W. Chen,  Daniel Williamson,  Khin Thway,  Robin L. Jones,  Maggie C. U. Cheang,  Paul H. Huang.

Nature Communications
Volume: 14, Issue: 1, Pages: 3834.

Clinical outcome of pediatric medulloblastoma patients with Li–Fraumeni syndrome

Anna S Kolodziejczak,  Lea Guerrini-Rousseau,  Julien Masliah Planchon,  Jonas Ecker,  Florian Selt,  Martin Mynarek,  Denise Obrecht,  Martin Sill,  Robert J Autry,  Eric Stutheit-Zhao,  Steffen Hirsch,  Elsa Amouyal,  Christelle Dufour,  Olivier Ayrault,  Jacob Torrejon,  Sebastian M Waszak,  Vijay Ramaswamy,  Virve Pentikainen,  Haci Ahmet Demir,  Steven C Clifford,  Ed C Schwalbe,  Luca Massimi,  Matija Snuderl,  Kristyn Galbraith,  Matthias A Karajannis,  Katherine Hill,  Bryan K Li,  Mike Walsh,  Christine L White,  Shelagh Redmond,  Loizou Loizos,  Marcus Jakob,  Uwe R Kordes,  Irene Schmid,  Julia Hauer,  Claudia Blattmann,  Maria Filippidou,  Gianluca Piccolo,  Wolfram Scheurlen,  Ahmed Farrag,  Kerstin Grund,  Christian Sutter,  Torsten Pietsch,  Stephan Frank,  Denis M Schewe,  David Malkin,  Myriam Ben-Arush,  Astrid Sehested,  Tai-Tong Wong,  Kuo-Sheng Wu,  Yen-Lin Liu,  Fernando Carceller,  Sabine Mueller,  Schuyler Stoller,  Michael D Taylor,  Uri Tabori,  Eric Bouffet,  Marcel Kool,  Felix Sahm,  Andreas von Deimling,  Andrey Korshunov,  Katja von Hoff,  Christian P Kratz,  Dominik Sturm,  David T W Jones,  Stefan Rutkowski,  Cornelis M van Tilburg,  Olaf Witt,  Gaëlle Bougeard,  Kristian W Pajtler,  Stefan M Pfister,  Franck Bourdeaut,  Till Milde.

Neuro-Oncology
Pages: noad114.

Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification

Jack Goddard,  Jemma Castle,  Emily Southworth,  Anya Fletcher,  Stephen Crosier,  Idoia Martin-Guerrero,  Miguel García-Ariza,  Aurora Navajas,  Julien Masliah-Planchon,  Franck Bourdeaut,  Christelle Dufour,  Olivier Ayrault,  Tobias Goschzik,  Torsten Pietsch,  Martin Sill,  Stefan M. Pfister,  Stefan Rutkowski,  Stacey Richardson,  Rebecca M. Hill,  Daniel Williamson,  Simon Bailey,  Edward C. Schwalbe,  Steven C. Clifford,  Debbie Hicks.

Acta Neuropathologica
Volume: 145, Issue: 5, Pages: 651-666.

Outcomes of Infants and Young Children With Relapsed Medulloblastoma After Initial Craniospinal Irradiation–Sparing Approaches: An International Cohort Study

Craig Erker,  Martin Mynarek,  Simon Bailey,  Claire M. Mazewski,  Lorena Baroni,  Maura Massimino,  Juliette Hukin,  Dolly Aguilera,  Andrea M. Cappellano,  Vijay Ramaswamy,  Alvaro Lassaletta,  Sébastien Perreault,  Cassie N. Kline,  Revathi Rajagopal,  George Michaiel,  Michal Zapotocky,  Vicente Santa-Maria Lopez,  Andres Morales La Madrid,  Chantel Cacciotti,  Eric S. Sandler,  Lindsey M. Hoffman,  Darren Klawinski,  Sara Khan,  Ralph Salloum,  Anna L. Hoppmann,  Valérie Larouche,  Kathleen Dorris,  Helen Toledano,  Stephen W. Gilheeney,  Mohamed S. Abdelbaki,  Beverly Wilson,  Derek S. Tsang,  Jeffrey Knipstein,  Michal Yalon Oren,  Shafqat Shah,  Jeffrey C. Murray,  Kevin F. Ginn,  Zhihong J. Wang,  Gudrun Fleischhack,  Denise Obrecht,  Svenja Tonn,  Virginia L. Harrod,  Kara Matheson,  Bruce Crooks,  Douglas R. Strother,  Kenneth J. Cohen,  Jordan R. Hansford,  Sabine Mueller,  Ashley Margol,  Amar Gajjar,  Girish Dhall,  Jonathan L. Finlay,  Paul A. Northcott,  Stefan Rutkowski,  Steven C. Clifford,  Giles Robinson,  Eric Bouffet,  Lucie Lafay-Cousin.

Journal of Clinical Oncology
Volume: 41, Issue: 10, Pages: 1921-1932.

Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemia

Sarra L. Ryan,  John F. Peden,  Zoya Kingsbury,  Claire J. Schwab,  Terena James,  Petri Polonen,  Martina Mijuskovic,  Jenn Becq,  Richard Yim,  Ruth E. Cranston,  Dale J. Hedges,  Kathryn G. Roberts,  Charles G. Mullighan,  Ajay Vora,  Lisa J. Russell,  Robert Bain,  Anthony V. Moorman,  David R. Bentley,  Christine J. Harrison,  Mark T. Ross.

Leukemia
Volume: 37, Issue: 3, Pages: 518-528.

Disruption to the FOXO-PRDM1 axis resulting from deletions of chromosome 6 in acute lymphoblastic leukaemia

Paul B. Sinclair,  Ruth E. Cranston,  Prahlad Raninga,  Joanna Cheng,  Rebecca Hanna,  Zoe Hawking,  Steven Hair,  Sarra L. Ryan,  Amir Enshaei,  Sirintra Nakjang,  Vikki Rand,  Helen J. Blair,  Anthony V. Moorman,  Olaf Heidenreich,  Christine J. Harrison.

Leukemia
Volume: 37, Issue: 3, Pages: 636-649.

Integrative genomic analysis of childhood acute lymphoblastic leukaemia lacking a genetic biomarker in the UKALL2003 clinical trial

Claire Schwab,  Ruth E. Cranston,  Sarra L. Ryan,  Ellie Butler,  Emily Winterman,  Zoe Hawking,  Matthew Bashton,  Amir Enshaei,  Lisa J. Russell,  Zoya Kingsbury,  John F. Peden,  Emilio Barretta,  James Murray,  Jude Gibson,  Andrew C. Hinchliffe,  Robert Bain,  Ajay Vora,  David R. Bentley,  Mark T. Ross,  Anthony V. Moorman,  Christine J. Harrison.

Leukemia
Volume: 37, Issue: 3, Pages: 529-538.

A microRNA expression signature in infant t(4;11) MLL-AF4+ BCP-ALL uncovers novel therapeutic targets

Camille Malouf,  Alasdair Duguid,  Giuseppina Camiolo,  Leslie Nitsche,  Hélène Jakobczyk,  Rishi S. Kotecha,  Richard A. Anderson,  Neil A. Barrett,  Owen P. Smith,  Katrin Ottersbach.

Clinical characteristics and outcomes of B-cell precursor ALL with MEF2D rearrangements: a retrospective study by the Ponte di Legno Childhood ALL Working Group

Kentaro Ohki,  Ellie R. Butler,  Nobutaka Kiyokawa,  Shinsuke Hirabayashi,  Anke K. Bergmann,  Anja Möricke,  Judith M. Boer,  Hélène Cavé,  Giovanni Cazzaniga,  Allen Eng Juh Yeoh,  Masashi Sanada,  Toshihiko Imamura,  Hiroto Inaba,  Charles G. Mullighan,  Mignon L. Loh,  Ulrika Norén-Nyström,  Lee-Yung Shih,  Marketa Zaliova,  Ching-Hon Pui,  Oskar A. Haas,  Christine J. Harrison,  Anthony V. Moorman,  Atsushi Manabe.

Leukemia
Volume: 37, Issue: 1, Pages: 212-216.

Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement

Simon Bomken,  Amir Enshaei,  Edward C. Schwalbe,  Aneta Mikulasova,  Yunfeng Dai,  Masood Zaka,  Kent T. M. Fung,  Matthew Bashton,  Huezin Lim,  Lisa Jones,  Nefeli Karataraki,  Emily Winterman,  Cody Ashby,  Andishe Attarbaschi,  Yves Bertrand,  Jutta Bradtke,  Barbara Buldini,  G. A. Amos Burke,  Giovanni Cazzaniga,  Gudrun Gohring,  Hesta A. de Groot-Kruseman,  Claudia Haferlach,  Luca Lo Nigro,  Mayur Parihar,  Adriana Plesa,  Emma Seaford,  Edwin Sonneveld,  Sabine Strehl,  Vincent H. J. van der Velden,  Vikki Rand,  Stephen P. Hunger,  Christine J. Harrison,  Chris M. Bacon,  Frederik W. van Delft,  Mignon L. Loh,  John Moppett,  Josef Vormoor,  Brian A. Walker,  Anthony V. Moorman,  Lisa J. Russell.

Haematologica
Volume: 108, Issue: 3, Pages: 717-731.

Timing is everything: A connection between medulloblastoma prognosis and foetal cerebellar development

Daniel Williamson,  Edward C. Schwalbe,  Simon Bailey,  Steven C. Clifford.

Neuropathology and Applied Neurobiology
Volume: 49, Issue: 3, Pages: e12903.

DNA methylation-based classification of glioneuronal tumours synergises with histology and radiology to refine accurate molecular stratification

Thomas J. Stone,  Kshitij Mankad,  Ai Peng Tan,  Wajanat Jan,  Jessica C. Pickles,  Maria Gogou,  Jane Chalker,  Iwona Slodkowska,  Emily Pang,  Mark Kristiansen,  Gaganjit K. Madhan,  Leysa Forrest,  Deborah Hughes,  Eleni Koutroumanidou,  Talisa Mistry,  Olumide Ogunbiyi,  Saira W. Ahmed,  J. Helen Cross,  Mike Hubank,  Darren Hargrave,  Thomas S. Jacques.

Neuropathology and Applied Neurobiology
Volume: 49, Issue: 2, Pages: e12894.

Human bone marrow organoids for disease modelling, discovery and validation of therapeutic targets in hematological malignancies

Abdullah O. Khan,  Antonio Rodriguez-Romera,  Jasmeet S. Reyat,  Aude-Anais Olijnik,  Michela Colombo,  Guanlin Wang,  Wei Xiong Wen,  Nikolaos Sousos,  Lauren C. Murphy,  Beata Grygielska,  Gina Perrella,  Christopher B. Mahony,  Rebecca E. Ling,  Natalina E. Elliott,  Christina Simoglou Karali,  Andrew P. Stone,  Samuel Kemble,  Emily A. Cutler,  Adele K. Fielding,  Adam P. Croft,  David Bassett,  Gowsihan Poologasundarampillai,  Anindita Roy,  Sarah Gooding,  Julie Rayes,  Kellie R. Machlus,  Bethan Psaila.

Cancer Discovery
Pages: CD-22-0199.

LGR5 targeting molecules as therapeutic agents for multiple cancer types

Hung-Chang Chen,  Nico Mueller,  Katherine Stott,  Eilidh Rivers,  Chrysa Kapeni,  Carolin M. Sauer,  Flavio Beke,  Stephen Walsh,  Nicola Ashman,  Louise O’Brien,  Amir Rafati Fard,  Arman Godsinia,  Fadwa Joud,  Olivier Giger,  Inti Zlobec,  Ioana Olan,  Sarah J. Aitken,  Matthew Hoare,  Richard Mair,  Eva Serrao,  James D. Brenton,  Alicia Garcia-Gimenez,  Simon E. Richardson,  Brian Huntly,  David R. Spring,  Mikkel-Ole Skjødt,  Karsten Skjødt,  Marc de la Roche,  Maike de la Roche.

Single-cell DNA sequencing identifies risk-associated clonal complexity and evolutionary trajectories in childhood medulloblastoma development

Marina Danilenko,  Masood Zaka,  Claire Keeling,  Stephen Crosier,  Stephanie Lyman,  Martina Finetti,  Daniel Williamson,  Rafiqul Hussain,  Jonathan Coxhead,  Peixun Zhou,  Rebecca M. Hill,  Debbie Hicks,  Vikki Rand,  Abhijit Joshi,  Edward C. Schwalbe,  Simon Bailey,  Steven C. Clifford.

Acta Neuropathologica
Volume: 144, Issue: 3, Pages: 565-578.

Clonal diversification and histogenesis of malignant germ cell tumours

Thomas R. W. Oliver,  Lia Chappell,  Rashesh Sanghvi,  Lauren Deighton,  Naser Ansari-Pour,  Stefan C. Dentro,  Matthew D. Young,  Tim H. H. Coorens,  Hyunchul Jung,  Tim Butler,  Matthew D. C. Neville,  Daniel Leongamornlert,  Mathijs A. Sanders,  Yvette Hooks,  Alex Cagan,  Thomas J. Mitchell,  Isidro Cortes-Ciriano,  Anne Y. Warren,  David C. Wedge,  Rakesh Heer,  Nicholas Coleman,  Matthew J. Murray,  Peter J. Campbell,  Raheleh Rahbari,  Sam Behjati.

Nature Communications
Volume: 13, Issue: 1, Pages: 4272.

Medulloblastoma group 3 and 4 tumors comprise a clinically and biologically significant expression continuum reflecting human cerebellar development

Daniel Williamson,  Edward C. Schwalbe,  Debbie Hicks,  Kimberly A. Aldinger,  Janet C. Lindsey,  Stephen Crosier,  Stacey Richardson,  Jack Goddard,  Rebecca M. Hill,  Jemma Castle,  Yura Grabovska,  James Hacking,  Barry Pizer,  Stephen B. Wharton,  Thomas S. Jacques,  Abhijit Joshi,  Simon Bailey,  Steven C. Clifford.

Cell Reports
Volume: 40, Issue: 5, Pages: 111162.

Anti-CCR9 chimeric antigen receptor T cells for T-cell acute lymphoblastic leukemia

Paul M. Maciocia,  Patrycja A. Wawrzyniecka,  Nicola C. Maciocia,  Amy Burley,  Thaneswari Karpanasamy,  Sam Devereaux,  Malika Hoekx,  David O’Connor,  Theresa Leon,  Tanya Rapoz-D’Silva,  Rachael Pocock,  Sunniyat Rahman,  Giuseppe Gritti,  Diana C. Yánez,  Susan Ross,  Tessa Crompton,  Owen Williams,  Lydia Lee,  Martin A. Pule,  Marc R. Mansour.

Blood
Volume: 140, Issue: 1, Pages: 25-37.

PAF1 and FACT cooperate with MLL-AF4 to drive enhancer activity in leukemia

Nicholas T. Crump,  Alastair Smith,  Laura Godfrey,  Nicole Jackson,  Siobhan Rice,  Jaehoon Kim,  Venkatesha Basrur,  Damian Fermin,  Kojo Elenitoba-Johnson,  Robert G. Roeder,  C. David Allis,  Irene Roberts,  Anindita Roy,  Thomas A. Milne.

PAF1 and FACT cooperate with MLL-AF4 to drive enhancer activity in leukemia

Nicholas T. Crump,  Alastair Smith,  Laura Godfrey,  Nicole Jackson,  Siobhan Rice,  Jaehoon Kim,  Venkatesha Basrur,  Damian Fermin,  Kojo Elenitoba-Johnson,  Robert G. Roeder,  C. David Allis,  Irene Roberts,  Anindita Roy,  Thomas A. Milne.

pRB-Depleted Pluripotent Stem Cell Retinal Organoids Recapitulate Cell State Transitions of Retinoblastoma Development and Suggest an Important Role for pRB in Retinal Cell Differentiation

Agata Rozanska,  Rodrigo Cerna-Chavez,  Rachel Queen,  Joseph Collin,  Darin Zerti,  Birthe Dorgau,  Chia Shyan Beh,  Tracey Davey,  Jonathan Coxhead,  Rafiqul Hussain,  Jumana Al-Aama,  David H Steel,  Nissim Benvenisty,  Lyle Armstrong,  Manoj Parulekar,  Majlinda Lako.

Stem Cells Translational Medicine
Volume: 11, Issue: 4, Pages: 415-433.

Genomic abnormalities of TP53 define distinct risk groups of paediatric B-cell non-Hodgkin lymphoma

Alexander M. Newman,  Masood Zaka,  Peixun Zhou,  Alex E. Blain,  Amy Erhorn,  Amy Barnard,  Rachel E. Crossland,  Sarah Wilkinson,  Amir Enshaei,  Julian De Zordi,  Fiona Harding,  Mary Taj,  Katrina M. Wood,  Despina Televantou,  Suzanne D. Turner,  G. A. Amos Burke,  Christine J. Harrison,  Simon Bomken,  Chris M. Bacon,  Vikki Rand.

Leukemia
Volume: 36, Issue: 3, Pages: 781-789.

Genetic characterisation of childhood B-other-acute lymphoblastic leukaemia in UK patients by fluorescence in situ hybridisation and Multiplex Ligation-dependent Probe Amplification

Claire J. Schwab,  Daniel Murdy,  Ellie Butler,  Amir Enshaei,  Emily Winterman,  Ruth E. Cranston,  Sarra Ryan,  Emilio Barretta,  Zoe Hawking,  James Murray,  Grace Antony,  Ajay Vora,  Anthony V. Moorman,  Christine J. Harrison.

British Journal of Haematology
Volume: 196, Issue: 3, Pages: 753-763.

DNA-thioguanine concentration and relapse risk in children and young adults with acute lymphoblastic leukemia: an IPD meta-analysis

Linea N. Toksvang,  Kathrine Grell,  Jacob Nersting,  Matilda Degn,  Stine N. Nielsen,  Jonas Abrahamsson,  Bendik Lund,  Jukka Kanerva,  Ólafur G. Jónsson,  Kristi Lepik,  Goda Vaitkeviciene,  Laimonas Griškevicius,  Petter Quist-Paulsen,  Ajay Vora,  Anthony V. Moorman,  Daniel Murdy,  Martin Zimmermann,  Anja Möricke,  Bruce Bostrom,  Jaitri Joshi,  Lisa L. Hjalgrim,  Kim P. Dalhoff,  Bodil Als-Nielsen,  Kjeld Schmiegelow.

Leukemia
Volume: 36, Issue: 1, Pages: 33-41.

Molecular characterisation and clinical outcome of B-cell precursor acute lymphoblastic leukaemia with IG-MYC rearrangement

Simon Bomken,  Amir Enshaei,  Edward C. Schwalbe,  Aneta Mikulasova,  Yunfeng Dai,  Masood Zaka,  Kent T. M. Fung,  Matthew Bashton,  Huezin Lim,  Lisa Jones,  Nefeli Karataraki,  Emily Winterman,  Cody Ashby,  Andishe Attarbaschi,  Yves Bertrand,  Jutta Bradtke,  Barbara Buldini,  G. A. Amos Burke,  Giovanni Cazzaniga,  Gudrun Gohring,  Hesta A. de Groot-Kruseman,  Claudia Haferlach,  Luca Lo Nigro,  Mayur Parihar,  Adriana Plesa,  Emma Seaford,  Edwin Sonneveld,  Sabine Strehl,  Vincent H. J. van der Velden,  Vikki Rand,  Stephen P. Hunger,  Christine J. Harrison,  Chris M. Bacon,  Frederik W. van Delft,  Mignon L. Loh,  John Moppett,  Josef Vormoor,  Brian A. Walker,  Anthony V. Moorman,  Lisa J. Russell.

Haematologica

Loss of ALK hotspot mutations in relapsed neuroblastoma

Lisa M. Allinson,  Aaron Potts,  Angharad Goodman,  Nick Bown,  Matthew Bashton,  Dean Thompson,  Nermine O. Basta,  Alem S. Gabriel,  Michael McCorkindale,  Antony Ng,  Richard J. Q. McNally,  Deborah A. Tweddle.

Genes, Chromosomes and Cancer
Volume: 61, Issue: 12, Pages: 747-753.

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program

Siobhan Rice,  Thomas Jackson,  Nicholas T. Crump,  Nicholas Fordham,  Natalina Elliott,  Sorcha O’Byrne,  Maria del Mar Lara Fanego,  Dilys Addy,  Trisevgeni Crabb,  Carryl Dryden,  Sarah Inglott,  Dariusz Ladon,  Gary Wright,  Jack Bartram,  Philip Ancliff,  Adam J. Mead,  Christina Halsey,  Irene Roberts,  Thomas A. Milne,  Anindita Roy.

Nature Communications
Volume: 12, Issue: 1, Pages: 6905.

miR-130b and miR-128a are essential lineage-specific codrivers of t(4;11) MLL-AF4 acute leukemia

Camille Malouf,  Eric T. B. Antunes,  Michael O’Dwyer,  Hélène Jakobczyk,  Franziska Sahm,  Sophie-Luise Landua,  Richard A. Anderson,  Abdenour Soufi,  Christina Halsey,  Katrin Ottersbach.

Blood
Volume: 138, Issue: 21, Pages: 2066-2092.

Karyosequencing: Integrating Genome-Wide and Targeted Sequencing for Comprehensive Diagnosis of Lymphoproliferative Disorders

James Peter Stewart,  Louise Harewood,  Shambhavi Srivastava,  Jana Gazdova,  Manisha Maurya,  Sirintra Nakjang,  Elizabeth Hodges,  Laura Chiecchio,  Nicholas C. P. Cross,  Matthew W Jenner,  Mark Catherwood,  Sarra Ryan,  Anthony V. Moorman,  Nikos Darzentas,  David Gonzalez.

Blood
Volume: 138, Pages: 272.

Anti-CD21 Chimeric Antigen Receptor (CAR)-T Cells for T Cell Acute Lymphoblastic Leukaemia (T-ALL)

Nicola C Maciocia,  Amy Burley,  Francesco Nannini,  Patrycja Wawrzyniecka,  Margarida Neves,  Thaneswari Karpanasamy,  Mathieu Ferrari,  Teresa Marafioti,  Shimobi Onuoha,  Asim Khwaja,  Paul M Maciocia,  Martin Pule.

Blood
Volume: 138, Issue: Supplement 1, Pages: 902.

Defining low-risk high hyperdiploidy in patients with paediatric acute lymphoblastic leukaemia: a retrospective analysis of data from the UKALL97/99 and UKALL2003 clinical trials

Amir Enshaei,  Ajay Vora,  Christine J Harrison,  John Moppett,  Anthony V Moorman.

The Lancet Haematology
Volume: 8, Issue: 11, Pages: e828-e839.

Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis

Chun Gong,  Joanna A. Krupka,  Jie Gao,  Nicholas F. Grigoropoulos,  George Giotopoulos,  Ryan Asby,  Michael Screen,  Zelvera Usheva,  Francesco Cucco,  Sharon Barrans,  Daniel Painter,  Nurmahirah Binte Mohammed Zaini,  Björn Haupl,  Susanne Bornelöv,  Igor Ruiz De Los Mozos,  Wei Meng,  Peixun Zhou,  Alex E. Blain,  Sorcha Forde,  Jamie Matthews,  Michelle Guet Khim Tan,  G. A. Amos Burke,  Siu Kwan Sze,  Philip Beer,  Cathy Burton,  Peter Campbell,  Vikki Rand,  Suzanne D. Turner,  Jernej Ule,  Eve Roman,  Reuben Tooze,  Thomas Oellerich,  Brian J. Huntly,  Martin Turner,  Ming-Qing Du,  Shamith A. Samarajiwa,  Daniel J. Hodson.

Molecular Cell
Volume: 81, Issue: 19, Pages: 4059-4075.e11.

Minimal residual disease, long-term outcome, and IKZF1 deletions in children and adolescents with Down syndrome and acute lymphocytic leukaemia: a matched cohort study

Naomi Michels,  Judith M Boer,  Amir Enshaei,  Rosemary Sutton,  Mats Heyman,  Sabine Ebert,  Marta Fiocco,  Hester A de Groot-Kruseman,  Vincent H J van der Velden,  Gisela Barbany,  Gabriele Escherich,  Ajay Vora,  Toby Trahair,  Luciano Dalla-Pozza,  Rob Pieters,  Udo zur Stadt,  Kjeld Schmiegelow,  Anthony V Moorman,  C Michel Zwaan,  Monique L den Boer.

The Lancet Haematology
Volume: 8, Issue: 10, Pages: e700-e710.

Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study

Judith M. Boer,  Maria Grazia Valsecchi,  Femke M. Hormann,  Željko Antic,  Marketa Zaliova,  Claire Schwab,  Giovanni Cazzaniga,  Chloé Arfeuille,  Hélène Cavé,  Andishe Attarbaschi,  Sabine Strehl,  Gabriele Escherich,  Toshihiko Imamura,  Kentaro Ohki,  Tanja A. Grüber,  Rosemary Sutton,  Agata Pastorczak,  Tim Lammens,  Frédéric Lambert,  Chi Kong Li,  Enrique Carrillo de Santa Pau,  Steve Hoffmann,  Anja Möricke,  Christine J. Harrison,  Monique L. Den Boer,  Paola De Lorenzo,  Ronald W. Stam,  Anke K. Bergmann,  Rob Pieters.

Leukemia
Volume: 35, Issue: 10, Pages: 2978-2982.

DNA-TG and risk of sinusoidal obstruction syndrome in childhood acute lymphoblastic leukemia

Linea Natalie Toksvang,  Kathrine Grell,  Stine Nygaard Nielsen,  Jacob Nersting,  Daniel Murdy,  Anthony V. Moorman,  Ajay Vora,  Kjeld Schmiegelow.

Leukemia
Volume: 36, Pages: 555-557.

Non-toxic polymer nanovectors for improved delivery of dexamethasone

Benjamin C. Ede,  Paraskevi Diamanti,  David S. Williams,  Allison Blair.

Scientific Reports
Volume: 11, Issue: 1, Pages: 17263.

Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging

Lucy E. Flint,  Gregory Hamm,  Joseph D. Ready,  Stephanie Ling,  Catherine J. Duckett,  Neil A. Cross,  Laura M. Cole,  David P. Smith,  Richard J. A. Goodwin,  Malcolm R. Clench.

Metabolites
Volume: 11, Issue: 8, Pages: 506.

Genome-wide analyses of XRN1-sensitive targets in osteosarcoma cells identifies disease-relevant transcripts containing G-rich motifs.

Amy L. Pashler,  Benjamin P. Towler,  Christopher I. Jones,  Hope J. Haime,  Tom Burgess,  Sarah F. Newbury.

RNA
Pages: rna.078872.121.

Abstract 2120: Interrogation of regulatory and expression changes in Malignant Rhabdoid Tumours to identify new therapeutic approaches

Emma L. Lishman-Walker,  Martina A. Finetti,  James P. Hacking,  Matthew Selby,  Yura Grabovska,  Stephen Crosier,  Simon Bailey,  Steven C. Clifford,  Daniel Williamson.

Cancer Research
Volume: 81, Issue: 13_Supplement, Pages: 2120.

Risk factors and outcomes in children with high-risk B-cell precursor and T-cell relapsed acute lymphoblastic leukaemia: combined analysis of ALLR3 and ALL-REZ BFM 2002 clinical trials

Cornelia Eckert,  Catriona Parker,  Anthony V. Moorman,  Julie Ae Irving,  Renate Kirschner-Schwabe,  Stefanie Groeneveld-Krentz,  Tamas Révész,  Peter Hoogerbrugge,  Jeremy Hancock,  Rosemary Sutton,  Guenter Henze,  Christiane Chen-Santel,  Andishe Attarbaschi,  Jean-Pierre Bourquin,  Lucie Sramkova,  Martin Zimmermann,  Shekhar Krishnan,  Arend von Stackelberg,  Vaskar Saha.

European Journal of Cancer (Oxford, England: 1990)
Volume: 151, Pages: 175-189.

MYB rearrangements and over-expression in T-cell acute lymphoblastic leukemia

Valentina Bardelli,  Silvia Arniani,  Valentina Pierini,  Tiziana Pierini,  Danika Di Giacomo,  Paolo Gorello,  Martina Moretti,  Fabrizia Pellanera,  Loredana Elia,  Antonella Vitale,  Clelia Tiziana Storlazzi,  Doron Tolomeo,  Elena Mastrodicasa,  Maurizio Caniglia,  Sabina Chiaretti,  Loredana Ruggeri,  Giovanni Roti,  Claire Schwab,  Christine J. Harrison,  André Almeida,  Tim Pieters,  Pieter Van Vlierberghe,  Cristina Mecucci,  Roberta La Starza.

Genes, Chromosomes & Cancer
Volume: 60, Issue: 7, Pages: 482-488.

SSBP2-CSF1R is a recurrent fusion in B-lineage acute lymphoblastic leukemia with diverse genetic presentation and variable outcome

Claire Schwab,  Kathryn Roberts,  Judith M. Boer,  Gudrun Göhring,  Doris Steinemann,  Ajay Vora,  Christine Macartney,  Rachael Hough,  Zoe Thorn,  Richard Dillon,  Gabriele Escherich,  Giovanni Cazzaniga,  Brigitte Schlegelberger,  Mignon Loh,  Monique L. den Boer,  Anthony V. Moorman,  Christine J. Harrison.

Blood
Volume: 137, Issue: 13, Pages: 1835-1838.

The <i>EBF1-PDGFRB</i> T681I mutation is highly resistant to imatinib and dasatinib <i>in vitro</i> and detectable in clinical samples prior to treatment

Thai Hoa Tran,  Jonathan V. Nguyen,  Adrian Stecula,  Jon Akutagawa,  Anthony V. Moorman,  Benjamin S. Braun,  Andrej Sali,  Charles G. Mullighan,  Neil P. Shah,  Yunfeng Dai,  Meenakshi Devidas,  Kathryn G. Roberts,  Catherine C. Smith,  Mignon L. Loh.

Haematologica
Volume: 106, Issue: 8, Pages: 2242-2245.

The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis

Ivo S. Muskens,  Shaobo Li,  Thomas Jackson,  Natalina Elliot,  Helen M. Hansen,  Swe Swe Myint,  Priyatama Pandey,  Jeremy M. Schraw,  Ritu Roy,  Joaquin Anguiano,  Katerina Goudevenou,  Kimberly D. Siegmund,  Philip J. Lupo,  Marella F. T. R. de Bruijn,  Kyle M. Walsh,  Paresh Vyas,  Xiaomei Ma,  Anindita Roy,  Irene Roberts,  Joseph L. Wiemels,  Adam J. de Smith.

Nature Communications
Volume: 12, Issue: 1, Pages: 821.

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia

Eleni Louka,  Benjamin Povinelli,  Alba Rodriguez-Meira,  Gemma Buck,  Wei Xiong Wen,  Guanlin Wang,  Nikolaos Sousos,  Neil Ashley,  Angela Hamblin,  Christopher A.G. Booth,  Anindita Roy,  Natalina Elliott,  Deena Iskander,  Josu de la Fuente,  Nicholas Fordham,  Sorcha O’Byrne,  Sarah Inglott,  Ruggiero Norfo,  Mariolina Salio,  Supat Thongjuea,  Anupama Rao,  Irene Roberts,  Adam J. Mead.

Journal of Experimental Medicine
Volume: 218, Issue: 2.

H3K79me2/3 controls enhancer–promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells

Laura Godfrey,  Nicholas T. Crump,  Sorcha O’Byrne,  I.-Jun Lau,  Siobhan Rice,  Joe R. Harman,  Thomas Jackson,  Natalina Elliott,  Gemma Buck,  Christopher Connor,  Ross Thorne,  David J. H. F. Knapp,  Olaf Heidenreich,  Paresh Vyas,  Pablo Menendez,  Sarah Inglott,  Philip Ancliff,  Huimin Geng,  Irene Roberts,  Anindita Roy,  Thomas A. Milne.

Leukemia
Volume: 35, Issue: 1, Pages: 90-106.

Single nucleotide polymorphism array-based signature of low hypodiploidy in acute lymphoblastic leukemia

Thomas Creasey,  Amir Enshaei,  Karin Nebral,  Claire Schwab,  Kathryn Watts,  Gavin Cuthbert,  Ajay Vora,  John Moppett,  Christine J. Harrison,  Adele K. Fielding,  Oskar A. Haas,  Anthony V. Moorman.

Genes, Chromosomes and Cancer
Volume: 60, Issue: 9, Pages: 604-615.

Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay

Gaëtan Juban,  Nathalie Sakakini,  Hedia Chagraoui,  David Cruz Hernandez,  Qian Cheng,  Kelly Soady,  Bilyana Stoilova,  Catherine Garnett,  Dominic Waithe,  Georg Otto,  Jessica Doondeea,  Batchimeg Usukhbayar,  Elena Karkoulia,  Maria Alexiou,  John Strouboulis,  Edward Morrissey,  Irene Roberts,  Catherine Porcher,  Paresh Vyas.

Haematologica
Volume: 106, Issue: 4, Pages: 1106-1119.

Biodegradable Nanovectors As a Direct Platform for the Controlled Delivery of Chemotherapeutic Drugs Against Childhood ALL

Benjamin C Ede,  Paraskevi Diamanti,  David C Williams,  Allison Blair.

Blood
Volume: 136, Issue: Supplement 1, Pages: 9.

CD1a is rarely expressed in pediatric or adult relapsed/refractory T-ALL: implications for immunotherapy

Sarah Leong,  Sarah Inglott,  Foteini Papaleonidopoulou,  Karen Orfinada,  Philip Ancliff,  Jack Bartram,  Ben Carpenter,  Adele K. Fielding,  Sara Ghorashian,  Victoria Grandage,  Rajeev Gupta,  Rachael Hough,  Asim Khwaja,  Vesna Pavasovic,  Anupama Rao,  Sujith Samarasinghe,  Ajay Vora,  Marc R. Mansour,  David O’Connor.

Blood Advances
Volume: 4, Issue: 19, Pages: 4665-4668.

Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on stearoyl-CoA desaturase

Angela Maria Savino,  Sara Isabel Fernandes,  Orianne Olivares,  Anna Zemlyansky,  Antony Cousins,  Elke K. Markert,  Shani Barel,  Ifat Geron,  Liron Frishman,  Yehudit Birger,  Cornelia Eckert,  Sergey Tumanov,  Gillian MacKay,  Jurre J. Kamphorst,  Pawel Herzyk,  Jonatan Fernández-García,  Ifat Abramovich,  Inbal Mor,  Michela Bardini,  Ersilia Barin,  Sudha Janaki-Raman,  Justin R. Cross,  Michael G. Kharas,  Eyal Gottlieb,  Shai Izraeli,  Christina Halsey.

Nature Cancer
Volume: 1, Issue: 10, Pages: 998-1009.

Leveraging Genome and Phenome-Wide Association Studies to Investigate Genetic Risk of Acute Lymphoblastic Leukemia

Eleanor C. Semmes,  Jayaram Vijayakrishnan,  Chenan Zhang,  Jillian H. Hurst,  Richard S. Houlston,  Kyle M. Walsh.

Cancer Epidemiology and Prevention Biomarkers
Volume: 29, Issue: 8, Pages: 1606-1614.

Phenotypic analysis of an MLL-AF4 gene regulatory network reveals indirect CASP9 repression as a mode of inducing apoptosis resistance

Joe R. Harman,  Ross Thorne,  Max Jamilly,  Marta Tapia,  Nicholas T. Crump,  Siobhan Rice,  Ryan Beveridge,  Edward Morrissey,  Marella F. T. R. de Bruijn,  Irene Roberts,  Anindita Roy,  Tudor A. Fulga,  Thomas A. Milne.

bioRxiv
Pages: 2020.06.30.179796.

Design of a Comprehensive Fluorescence in Situ Hybridization Assay for Genetic Classification of T-Cell Acute Lymphoblastic Leukemia

Roberta La Starza,  Valentina Pierini,  Tiziana Pierini,  Valeria Nofrini,  Caterina Matteucci,  Silvia Arniani,  Martina Moretti,  Anair G. Lema Fernandez,  Fabrizia Pellanera,  Danika Di Giacomo,  Tiziana C. Storlazzi,  Antonella Vitale,  Paolo Gorello,  Gabriella Sammarelli,  Giovanni Roti,  Giuseppe Basso,  Sabina Chiaretti,  Robin Foà,  Claire Schwab,  Christine J. Harrison,  Pieter Van Vlierberghe,  Cristina Mecucci.

The Journal of Molecular Diagnostics
Volume: 22, Issue: 5, Pages: 629-639.

A validated novel continuous prognostic index to deliver stratified medicine in pediatric acute lymphoblastic leukemia

Amir Enshaei,  David O’Connor,  Jack Bartram,  Jeremy Hancock,  Christine J. Harrison,  Rachael Hough,  Sujith Samarasinghe,  Monique L. den Boer,  Judith M. Boer,  Hester A. de Groot-Kruseman,  Hanne V. Marquart,  Ulrika Noren-Nystrom,  Kjeld Schmiegelow,  Claire Schwab,  Martin A. Horstmann,  Gabriele Escherich,  Mats Heyman,  Rob Pieters,  Ajay Vora,  John Moppett,  Anthony V. Moorman.

Blood
Volume: 135, Issue: 17, Pages: 1438-1446.

H3K79me2/3 controls enhancer–promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells

Laura Godfrey,  Nicholas T. Crump,  Sorcha O’Byrne,  I-Jun Lau,  Siobhan Rice,  Joe R. Harman,  Thomas Jackson,  Natalina Elliott,  Gemma Buck,  Christopher Connor,  Ross Thorne,  David J. H. F. Knapp,  Olaf Heidenreich,  Paresh Vyas,  Pablo Menendez,  Sarah Inglott,  Philip Ancliff,  Huimin Geng,  Irene Roberts,  Anindita Roy,  Thomas A. Milne.

Leukemia

Germline variants in predisposition genes in children with Down syndrome and acute lymphoblastic leukemia

Peleg Winer,  Ivo S. Muskens,  Kyle M. Walsh,  Ajay Vora,  Anthony V. Moorman,  Joseph L. Wiemels,  Irene Roberts,  Anindita Roy,  Adam J. de Smith.

Blood Advances
Volume: 4, Issue: 4, Pages: 672-675.

Concordance of copy number abnormality detection using SNP arrays and Multiplex Ligation-dependent Probe Amplification (MLPA) in acute lymphoblastic leukaemia

Matthew Bashton,  Robin Hollis,  Sarra Ryan,  Claire J. Schwab,  John Moppett,  Christine J. Harrison,  Anthony V. Moorman,  Amir Enshaei.

Scientific Reports
Volume: 10, Issue: 1, Pages: 45.

Molecular characterisation and clinical outcome of B-cell precursor acute lymphoblastic leukaemia with IG-MYC rearrangement

Simon Bomken,  Amir Enshaei,  Edward C. Schwalbe,  Aneta Mikulasova,  Yunfeng Dai,  Masood Zaka,  Kent T. M. Fung,  Matthew Bashton,  Huezin Lim,  Lisa Jones,  Nefeli Karataraki,  Emily Winterman,  Cody Ashby,  Andishe Attarbaschi,  Yves Bertrand,  Jutta Bradtke,  Barbara Buldini,  G. A. Amos Burke,  Giovanni Cazzaniga,  Gudrun Gohring,  Hesta A. de Groot-Kruseman,  Claudia Haferlach,  Luca Lo Nigro,  Mayur Parihar,  Adriana Plesa,  Emma Seaford,  Edwin Sonneveld,  Sabine Strehl,  Vincent H. J. van der Velden,  Vikki Rand,  Stephen P. Hunger,  Christine J. Harrison,  Chris M. Bacon,  Frederik W. van Delft,  Mignon L. Loh,  John Moppett,  Josef Vormoor,  Brian A. Walker,  Anthony V. Moorman,  Lisa J. Russell.

Haematologica

Adjuvant tyrosine kinase inhibitor therapy improves outcome for children and adolescents with acute lymphoblastic leukaemia who have an ABL-class fusion

Anthony V. Moorman,  Claire Schwab,  Emily Winterman,  Jerry Hancock,  Anna Castleton,  Michelle Cummins,  Brenda Gibson,  Nick Goulden,  Pam Kearns,  Beki James,  Amy A. Kirkwood,  Donna Lancaster,  Mabrouk Madi,  Andrew McMillan,  Jayashree Motwani,  Alice Norton,  Aengus O’Marcaigh,  Katharine Patrick,  Neha Bhatnagar,  Amrana Qureshi,  Deborah Richardson,  Simone Stokley,  Gordon Taylor,  Frederik W. van Delft,  John Moppett,  Christine J. Harrison,  Sujith Samarasinghe,  Ajay Vora.

British Journal of Haematology
Volume: 191, Issue: 5, Pages: 844-851.

Trisomy 21 Driven Pro-Inflammatory Signalling in Fetal Bone Marrow May Play a Role in Perturbed B-Lymphopoiesis and Acute Lymphoblastic Leukemia of Down Syndrome

Sorcha Isabella O'Byrne,  Natalina Elliott,  Gemma Buck,  Siobhan Rice,  David O'Connor,  Jana Oswald,  Hannah Fuchs,  Ella-Mae Labbett,  Nicholas James Fordham,  Anindita Roy,  Irene Roberts.

Blood
Volume: 134, Issue: Supplement_1, Pages: 1206-1206.

MIR-128A AND MIR-130B DETERMINE LINEAGE CHOICE AND LEUKEMIA-PROPAGATING CELL IDENTITY IN MLL-AF4+ ACUTE LEUKEMIA

Katrin Ottersbach,  Camille Malouf,  Franziska Sahm,  Sophie-Luise Landua.

Experimental Hematology
Volume: 76, Pages: S81.

PF153 MLL-AF4 CAUSES ABERRANT UPREGULATION OF PROM1 (CD133) IN ACUTE LYMPHOBLASTIC LEUKEMIA BY CONTROLLING ENHANCER-PROMOTER INTERACTIONS

L. Godfrey,  S. O’Byrne,  N. T. Crump,  I.-J. Lau,  R. Thorne,  N. Elliott,  G. Buck,  S. Rice,  C. Connor,  R. Thomas,  D. Cheng,  P. Ancliff,  S. Inglott,  I. Roberts,  A. Roy,  T. A. Milne.

HemaSphere
Volume: 3, Issue: S1, Pages: 29.

Outcomes of patients with childhood B-cell precursor acute lymphoblastic leukaemia with late bone marrow relapses: long-term follow-up of the ALLR3 open-label randomised trial

Catriona Parker,  Shekhar Krishnan,  Lina Hamadeh,  Julie A. E. Irving,  Roland P. Kuiper,  Tamas Révész,  Peter Hoogerbrugge,  Jeremy Hancock,  Rosemary Sutton,  Anthony V. Moorman,  Vaskar Saha.

The Lancet. Haematology
Volume: 6, Issue: 4, Pages: e204-e216.

Trypsin-encoding PRSS1-PRSS2 variations influence the risk of asparaginase-associated pancreatitis in children with acute lymphoblastic leukemia: a Ponte di Legno toxicity working group report

Benjamin O. Wolthers,  Thomas L. Frandsen,  Chirag J. Patel,  Rachid Abaji,  Andishe Attarbaschi,  Shlomit Barzilai,  Antonella Colombini,  Gabriele Escherich,  Marie Grosjean,  Maja Krajinovic,  Eric Larsen,  Der-Cherng Liang,  Anja Möricke,  Kirsten K. Rasmussen,  Sujith Samarasinghe,  Lewis B. Silverman,  Inge M. van der Sluis,  Martin Stanulla,  Morten Tulstrup,  Rachita Yadav,  Wenjian Yang,  Ester Zapotocka,  Ramneek Gupta,  Kjeld Schmiegelow,  Ponte di Legno toxicity working group.

Haematologica
Volume: 104, Issue: 3, Pages: 556-563.

The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL

Kim R. Kampen,  Sergey O. Sulima,  Benno Verbelen,  Tiziana Girardi,  Stijn Vereecke,  Gianmarco Rinaldi,  Jelle Verbeeck,  Joyce Op de Beeck,  Anne Uyttebroeck,  Jules P. P. Meijerink,  Anthony V. Moorman,  Christine J. Harrison,  Pieter Spincemaille,  Jan Cools,  David Cassiman,  Sarah-Maria Fendt,  Pieter Vermeersch,  Kim De Keersmaecker.

Leukemia
Volume: 33, Issue: 2, Pages: 319-332.

The journey to CAR T cell therapy: the pediatric and young adult experience with relapsed or refractory B-ALL

George Hucks,  Susan R. Rheingold.

Blood Cancer Journal
Volume: 9, Issue: 2, Pages: 10.

Validation of the United Kingdom copy-number alteration classifier in 3239 children with B-cell precursor ALL

Lina Hamadeh,  Amir Enshaei,  Claire Schwab,  Cristina N. Alonso,  Andishe Attarbaschi,  Gisela Barbany,  Monique L. den Boer,  Judith M. Boer,  Marcin Braun,  Luciano Dalla Pozza,  Sarah Elitzur,  Mariana Emerenciano,  Larisa Fechina,  Maria Sara Felice,  Eva Fronkova,  Irén Haltrich,  Mats M. Heyman,  Keizo Horibe,  Toshihiko Imamura,  Marta Jeison,  Gábor Kovács,  Roland P. Kuiper,  Wojciech Mlynarski,  Karin Nebral,  Ingegerd Ivanov Öfverholm,  Agata Pastorczak,  Rob Pieters,  Henriett Piko,  Maria S. Pombo-de-Oliveira,  Patricia Rubio,  Sabine Strehl,  Jan Stary,  Rosemary Sutton,  Jan Trka,  Grigory Tsaur,  Nicola Venn,  Ajay Vora,  Mio Yano,  Christine J. Harrison,  Anthony V. Moorman,  International BFM Study Group.

Blood Advances
Volume: 3, Issue: 2, Pages: 148-157.

Long-term follow up of pediatric Philadelphia positive acute lymphoblastic leukemia treated with the EsPhALL2004 study: high white blood cell count at diagnosis is the strongest prognostic factor

Andrea Biondi,  Gunnar Cario,  Paola De Lorenzo,  Anders Castor,  Valentino Conter,  Veronica Leoni,  Virginie Gandemer,  Rob Pieters,  Jan Stary,  Gabriele Escherich,  Myriam Campbell,  Andishe Attarbaschi,  Chi-Kong Li,  Ajay Vora,  Jutta Bradtke,  Vaskar Saha,  Maria Grazia Valsecchi,  Martin Schrappe.

Haematologica
Volume: 104, Issue: 1, Pages: e13-e16.

Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia

Gloria Milani,  Filip Matthijssens,  Wouter Van Loocke,  Kaat Durinck,  Juliette Roels,  Sofie Peirs,  Morgan Thénoz,  Tim Pieters,  Lindy Reunes,  Beatrice Lintermans,  Niels Vandamme,  Tim Lammens,  Nadine Van Roy,  Filip Van Nieuwerburgh,  Dieter Deforce,  Claire Schwab,  Susana Raimondi,  Luciano Dalla Pozza,  Andrew J. Carroll III,  Barbara De Moerloose,  Yves Benoit,  Steven Goossens,  Geert Berx,  Christine J. Harrison,  Giuseppe Basso,  Hélène Cavé,  Rosemary Sutton,  Vahid Asnafi,  Jules Meijerink,  Charles Mullighan,  Mignon Loh,  Pieter Van Vlierberghe.

British Journal of Haematology
Volume: 185, Issue: 1, Pages: 169-174.

SH2B3 inactivation through CN-LOH 12q is uniquely associated with B-cell precursor ALL with iAMP21 or other chromosome 21 gain

Paul B. Sinclair,  Sarra Ryan,  Matthew Bashton,  Shaun Hollern,  Rebecca Hanna,  Marian Case,  Edward C. Schwalbe,  Claire J. Schwab,  Ruth E. Cranston,  Brian D. Young,  Julie A. E. Irving,  Ajay J. Vora,  Anthony V. Moorman,  Christine J. Harrison.

Leukemia
Volume: 33, Issue: 8, Pages: 1881-1894.

Impact of dose and duration of therapy on dexamethasone pharmacokinetics in childhood acute lymphoblastic leukaemia—a report from the UKALL 2011 trial

Rosanna K. Jackson,  Martina Liebich,  Philip Berry,  Julie Errington,  Jizhong Liu,  Catriona Parker,  John Moppett,  Sujith Samarasinghe,  Rachael Hough,  Clare Rowntree,  Nick J. Goulden,  Ajay Vora,  Pamela R. Kearns,  Vaskar Saha,  Georg Hempel,  Julie A.E. Irving,  Gareth J. Veal.

European Journal of Cancer
Volume: 120, Pages: 75-85.

Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk

Jayaram Vijayakrishnan,  Maoxiang Qian,  James B. Studd,  Wenjian Yang,  Ben Kinnersley,  Philip J. Law,  Peter Broderick,  Elizabeth A. Raetz,  James Allan,  Ching-Hon Pui,  Ajay Vora,  William E. Evans,  Anthony Moorman,  Allen Yeoh,  Wentao Yang,  Chunliang Li,  Claus R. Bartram,  Charles G. Mullighan,  Martin Zimmerman,  Stephen P. Hunger,  Martin Schrappe,  Mary V. Relling,  Martin Stanulla,  Mignon L. Loh,  Richard S. Houlston,  Jun J. Yang.

Nature Communications
Volume: 10, Issue: 1, Pages: 5348.

Imatinib treatment of paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (EsPhALL2010): a prospective, intergroup, open-label, single-arm clinical trial

Andrea Biondi,  Virginie Gandemer,  Paola De Lorenzo,  Gunnar Cario,  Myriam Campbell,  Anders Castor,  Rob Pieters,  André Baruchel,  Ajay Vora,  Veronica Leoni,  Jan Stary,  Gabriele Escherich,  Chi-Kong Li,  Giovanni Cazzaniga,  Hélène Cavé,  Jutta Bradtke,  Valentino Conter,  Vaskar Saha,  Martin Schrappe,  Maria Grazia Valsecchi.

The Lancet. Haematology
Volume: 5, Issue: 12, Pages: e641-e652.

Single-cell analysis identifies CRLF2 rearrangements as both early and late events in Down syndrome and non-Down syndrome acute lymphoblastic leukaemia

N. Potter,  L. Jones,  H. Blair,  S. Strehl,  C. J. Harrison,  M. Greaves,  L. Kearney,  L. J. Russell.

Leukemia
Volume: 33, Pages: 893-904.

Successes and challenges in the treatment of pediatric acute myeloid leukemia: a retrospective analysis of the AML-BFM trials from 1987 to 2012

Mareike Rasche,  Martin Zimmermann,  Lisa Borschel,  Jean-Pierre Bourquin,  Michael Dworzak,  Thomas Klingebiel,  Thomas Lehrnbecher,  Ursula Creutzig,  Jan-Henning Klusmann,  Dirk Reinhardt.

Leukemia
Volume: 32, Issue: 10, Pages: 2167.

Prediction of asparaginase-associated pancreatitis in children with acute lymphoblastic leukemia

Rikke Linnemann Nielsen,  Benjamin Ole Wolthers,  Marianne Helenius,  Kjeld Schmiegelow,  Ramneek Gupta.

Oral presentation 13th International Conference on Genomics, Shenzen, China
Pages: 1.

The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia

Caroline L. Furness,  Marcela B. Mansur,  Victoria J. Weston,  Luca Ermini,  Frederik W. van Delft,  Sarah Jenkinson,  Rosemary Gale,  Christine J. Harrison,  Maria S. Pombo-de-Oliveira,  Marta Sanchez-Martin,  Adolfo A. Ferrando,  Pamela Kearns,  Ian Titley,  Anthony M. Ford,  Nicola E. Potter,  Mel Greaves.

Leukemia
Volume: 32, Issue: 9, Pages: 1984-1993.

TCRaß/CD3 disruption enables CD3-specific antileukemic T cell immunotherapy

Jane Rasaiyaah,  Christos Georgiadis,  Roland Preece,  Ulrike Mock,  Waseem Qasim.

JCI insight
Volume: 3, Issue: 13.

Prognostic impact of the absence of biallelic deletion at the TRG locus for pediatric patients with T-cell acute lymphoblastic leukemia treated on the Medical Research Council UK Acute Lymphoblastic Leukemia 2003 trial

Nadine Farah,  Amy A. Kirkwood,  Sunniyat Rahman,  Theresa Leon,  Sarah Jenkinson,  Rosemary E. Gale,  Katharine Patrick,  Jeremy Hancock,  Sujith Samarasinghe,  David C. Linch,  Anthony V. Moorman,  Nicholas Goulden,  Ajay Vora,  Marc R. Mansour.

Haematologica
Volume: 103, Issue: 7, Pages: e288-e292.

Genotype-Specific Minimal Residual Disease Interpretation Improves Stratification in Pediatric Acute Lymphoblastic Leukemia

David O'Connor,  Amir Enshaei,  Jack Bartram,  Jeremy Hancock,  Christine J. Harrison,  Rachael Hough,  Sujith Samarasinghe,  Claire Schwab,  Ajay Vora,  Rachel Wade,  John Moppett,  Anthony V. Moorman,  Nick Goulden.

Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Volume: 36, Issue: 1, Pages: 34-43.

Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21

Paul B. Sinclair,  Helen H. Blair,  Sarra L. Ryan,  Lars Buechler,  Joanna Cheng,  Jake Clayton,  Rebecca Hanna,  Shaun Hollern,  Zoe Hawking,  Matthew Bashton,  Claire J. Schwab,  Lisa Jones,  Lisa J. Russell,  Helen Marr,  Peter Carey,  Christina Halsey,  Olaf Heidenreich,  Anthony V. Moorman,  Christine J. Harrison.

Haematologica
Volume: 103, Issue: 4, Pages: 634-644.

Predictive value of minimal residual disease in Philadelphia-chromosome-positive acute lymphoblastic leukemia treated with imatinib in the European intergroup study of post-induction treatment of Philadelphia-chromosome-positive acute lymphoblastic leukemia, based on immunoglobulin/T-cell receptor and BCR/ABL1 methodologies

Giovanni Cazzaniga,  Paola De Lorenzo,  Julia Alten,  Silja Röttgers,  Jeremy Hancock,  Vaskar Saha,  Anders Castor,  Hans O. Madsen,  Virginie Gandemer,  Hélène Cavé,  Veronica Leoni,  Rolf Köhler,  Giulia M. Ferrari,  Kirsten Bleckmann,  Rob Pieters,  Vincent van der Velden,  Jan Stary,  Jan Zuna,  Gabriele Escherich,  Udo Zur Stadt,  Maurizio Aricò,  Valentino Conter,  Martin Schrappe,  Maria Grazia Valsecchi,  Andrea Biondi.

Haematologica
Volume: 103, Issue: 1, Pages: 107-115.

Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia

Jayaram Vijayakrishnan,  James Studd,  Peter Broderick,  Ben Kinnersley,  Amy Holroyd,  Philip J. Law,  Rajiv Kumar,  James M. Allan,  Christine J. Harrison,  Anthony V. Moorman,  Ajay Vora,  Eve Roman,  Sivaramakrishna Rachakonda,  Sally E. Kinsey,  Eamonn Sheridan,  Pamela D. Thompson,  Julie A. Irving,  Rolf Koehler,  Per Hoffmann,  Markus M. Nöthen,  Stefanie Heilmann-Heimbach,  Karl-Heinz Jöckel,  Douglas F. Easton,  Paul D. P. Pharaoh,  Alison M. Dunning,  Julian Peto,  Frederico Canzian,  Anthony Swerdlow,  Rosalind A. Eeles,  ZSofia Kote-Jarai,  Kenneth Muir,  Nora Pashayan,  PRACTICAL Consortium,  Mel Greaves,  Martin Zimmerman,  Claus R. Bartram,  Martin Schrappe,  Martin Stanulla,  Kari Hemminki,  Richard S. Houlston.

Nature Communications
Volume: 9, Issue: 1, Pages: 1340.

The genetic basis and cell of origin of mixed phenotype acute leukaemia

Thomas B. Alexander,  Zhaohui Gu,  Ilaria Iacobucci,  Kirsten Dickerson,  John K. Choi,  Beisi Xu,  Debbie Payne-Turner,  Hiroki Yoshihara,  Mignon L. Loh,  John Horan,  Barbara Buldini,  Giuseppe Basso,  Sarah Elitzur,  Valerie de Haas,  C. Michel Zwaan,  Allen Yeoh,  Dirk Reinhardt,  Daisuke Tomizawa,  Nobutaka Kiyokawa,  Tim Lammens,  Barbara De Moerloose,  Daniel Catchpoole,  Hiroki Hori,  Anthony Moorman,  Andrew S. Moore,  Ondrej Hrusak,  Soheil Meshinchi,  Etan Orgel,  Meenakshi Devidas,  Michael Borowitz,  Brent Wood,  Nyla A. Heerema,  Andrew Carrol,  Yung-Li Yang,  Malcolm A. Smith,  Tanja M. Davidsen,  Leandro C. Hermida,  Patee Gesuwan,  Marco A. Marra,  Yussanne Ma,  Andrew J. Mungall,  Richard A. Moore,  Steven J. M. Jones,  Marcus Valentine,  Laura J. Janke,  Jeffrey E. Rubnitz,  Ching-Hon Pui,  Liang Ding,  Yu Liu,  Jinghui Zhang,  Kim E. Nichols,  James R. Downing,  Xueyuan Cao,  Lei Shi,  Stanley Pounds,  Scott Newman,  Deqing Pei,  Jaime M. Guidry Auvil,  Daniela S. Gerhard,  Stephen P. Hunger,  Hiroto Inaba,  Charles G. Mullighan.

Nature
Volume: 562, Issue: 7727, Pages: 373-379.

Molecular and Functional Characterization of Disease-Propagating Stem Cells in Juvenile Myelomonocytic Leukemia

Eleni Louka,  Benjamin Povinelli,  Alba Rodriguez-Meira,  Gemma Buck,  Angela Hamblin,  Christopher Booth,  Anindita Roy,  Natalina Elliott,  Deena Iskander,  Josu de la Fuente,  Nicholas James Fordham,  Sorcha Isabella Obyrne,  Sarah Inglott,  Anupama Gopala Rao,  Irene Roberts,  Adam J. Mead.

Blood
Volume: 130, Issue: Suppl 1, Pages: 379-379.

Common Genetic Variants in Trypsin Regulating Genes Are Associated with AsparAginase-Associated Pancreatitis in Children with Acute Lymphoblastic Leukemia: A Ponte Di Legno Toxicity Working Group Study

Benjamin Ole Wolthers,  Thomas Leth Frandsen,  Andishe Attarbaschi,  Shlomit Barzilai,  Antonella Colombini,  Gabriele Escherich,  Marie Grosjean,  Ramneek Gupta,  Der-Cherng Liang,  Anja Moricke,  Chirag J. Patel,  Kirsten K. Rasmussen,  Sujith Samarasinghe,  Inge M. Van Der Sluis,  Martin Stanulla,  Morten Tulstrup,  Ester Zapotocka,  Kjeld Schmiegelow.

Blood
Volume: 130, Issue: Suppl 1, Pages: 885-885.

miR-128a, miR-130b and miR-155 are co-drivers of T(4;11) Mll-AF4 acute lymphoblastic leukaemia

Camille Malouf,  Franziska Sahm,  Chrysa Kapeni,  Katrin Ottersbach.

Experimental Hematology
Volume: 53, Pages: S80.

Intragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?

Claire Schwab,  Karin Nebral,  Lucy Chilton,  Cristina Leschi,  Esmé Waanders,  Judith M. Boer,  Markéta Žaliová,  Rosemary Sutton,  Ingegerd Ivanov Öfverholm,  Kentaro Ohki,  Yuka Yamashita,  Stefanie Groeneveld-Krentz,  Eva Fronková,  Marleen Bakkus,  Joelle Tchinda,  Thayana da Conceição Barbosa,  Grazia Fazio,  Wojciech Mlynarski,  Agata Pastorczak,  Giovanni Cazzaniga,  Maria S. Pombo-de-Oliveira,  Jan Trka,  Renate Kirschner-Schwabe,  Toshihiko Imamura,  Gisela Barbany,  Martin Stanulla,  Andishe Attarbaschi,  Renate Panzer-Grümayer,  Roland P. Kuiper,  Monique L. den Boer,  Hélène Cavé,  Anthony V. Moorman,  Christine J. Harrison,  Sabine Strehl.

Blood Advances
Volume: 1, Issue: 19, Pages: 1473-1477.

Re-ordering the B cell developmental hierarchy in fetal life; characterisation of a novel human B progenitor

O'Byrne, Sorcha,  Elliott, Natalina,  Buck, Gemma,  Liu, Binbin,  Povinelli, Benjamin,  Fordham, Nicholas,  Louka, Eleni,  Bartolovic, Kerol,  Karadimitris, Anastasios,  Mead, Adam,  Roberts, Irene,  Roy, Anindita.

Volume: 102, Pages: 80-80.

Integrating Tenascin-C protein expression and 1q25 copy number status in pediatric intracranial ependymoma prognostication: A new model for risk stratification

Felipe Andreiuolo,  Gwénaël Le Teuff,  Mohamed Amine Bayar,  John-Paul Kilday,  Torsten Pietsch,  André O. von Bueren,  Hendrik Witt,  Andrey Korshunov,  Piergiorgio Modena,  Stefan M. Pfister,  Mélanie Pagès,  David Castel,  Felice Giangaspero,  Leila Chimelli,  Pascale Varlet,  Stefan Rutkowski,  Didier Frappaz,  Maura Massimino,  Richard Grundy,  Jacques Grill,  on behalf of the SIOP Ependymoma Biology Working Group BIOMECA (BIOlogical Markers for Ependymomas in Children and Adolescents).

PLOS ONE
Volume: 12, Issue: 6, Pages: e0178351.

Genomic architecture and treatment outcome in pediatric acute myeloid leukemia: a Children’s Oncology Group report

Marijana Vujkovic,  Edward F. Attiyeh,  Rhonda E. Ries,  Elizabeth K. Goodman,  Yang Ding,  Marko Kavcic,  Todd A. Alonzo,  Yi-Cheng Wang,  Robert B. Gerbing,  Lillian Sung,  Betsy Hirsch,  Susana Raimondi,  Alan S. Gamis,  Soheil Meshinchi,  Richard Aplenc.

Blood
Volume: 129, Issue: 23, Pages: 3051-3058.

Acute lymphoblastic leukaemia cells produce large extracellular vesicles containing organelles and an active cytoskeleton

Suzanne M. Johnson,  Clare Dempsey,  Catriona Parker,  Aleksandr Mironov,  Helen Bradley,  Vaskar Saha.

Journal of Extracellular Vesicles
Volume: 6, Issue: 1, Pages: 1294339.

Use of Minimal Residual Disease Assessment to Redefine Induction Failure in Pediatric Acute Lymphoblastic Leukemia

David O'Connor,  Anthony V. Moorman,  Rachel Wade,  Jeremy Hancock,  Ronald M. R. Tan,  Jack Bartram,  John Moppett,  Claire Schwab,  Katharine Patrick,  Christine J. Harrison,  Rachael Hough,  Nick Goulden,  Ajay Vora,  Sujith Samarasinghe.

Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Volume: 35, Issue: 6, Pages: 660-667.

Adaptive from Innate: Human IFN-?+CD4+ T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults

Abhishek Das,  Kevin Rouault-Pierre,  Shraddha Kamdar,  Iria Gomez-Tourino,  Kristie Wood,  Ian Donaldson,  Charles A. Mein,  Dominique Bonnet,  Adrian C. Hayday,  Deena L. Gibbons.

Journal of Immunology (Baltimore, Md.: 1950)
Volume: 199, Issue: 5, Pages: 1696-1705.

High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans

Anindita Roy,  Vojtech Bystry,  Georg Bohn,  Katerina Goudevenou,  Tomas Reigl,  Maria Papaioannou,  Adam Krejci,  Sorcha O'Byrne,  Aristeidis Chaidos,  Andrea Grioni,  Nikos Darzentas,  Irene A. G. Roberts,  Anastasios Karadimitris.

Clinical Immunology (Orlando, Fla.)
Volume: 183, Pages: 8-16.

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia

Sunniyat Rahman,  Michael Magnussen,  Theresa E. León,  Nadine Farah,  Zhaodong Li,  Brian J. Abraham,  Krisztina Z. Alapi,  Rachel J. Mitchell,  Tom Naughton,  Adele K. Fielding,  Arnold Pizzey,  Sophia Bustraan,  Christopher Allen,  Teodora Popa,  Karin Pike-Overzet,  Laura Garcia-Perez,  Rosemary E. Gale,  David C. Linch,  Frank J. T. Staal,  Richard A. Young,  A. Thomas Look,  Marc R. Mansour.

Blood
Volume: 129, Issue: 24, Pages: 3221-3226.

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Jon Kerry,  Laura Godfrey,  Emmanouela Repapi,  Marta Tapia,  Neil P. Blackledge,  Helen Ma,  Erica Ballabio,  Sorcha O'Byrne,  Frida Ponthan,  Olaf Heidenreich,  Anindita Roy,  Irene Roberts,  Marina Konopleva,  Robert J. Klose,  Huimin Geng,  Thomas A. Milne.

Cell Reports
Volume: 18, Issue: 2, Pages: 482-495.

Small genomic insertions form enhancers that misregulate oncogenes

Brian J. Abraham,  Denes Hnisz,  Abraham S. Weintraub,  Nicholas Kwiatkowski,  Charles H. Li,  Zhaodong Li,  Nina Weichert-Leahey,  Sunniyat Rahman,  Yu Liu,  Julia Etchin,  Benshang Li,  Shuhong Shen,  Tong Ihn Lee,  Jinghui Zhang,  A. Thomas Look,  Marc R. Mansour,  Richard A. Young.

Nature Communications
Volume: 8, Pages: 14385.

A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1

J. Vijayakrishnan,  R. Kumar,  M. Y. R. Henrion,  A. V. Moorman,  P. S. Rachakonda,  I. Hosen,  M. I. da Silva Filho,  A. Holroyd,  S. E. Dobbins,  R. Koehler,  H. Thomsen,  J. A. Irving,  J. M. Allan,  T. Lightfoot,  E. Roman,  S. E. Kinsey,  E. Sheridan,  P. D. Thompson,  P. Hoffmann,  M. M. Nöthen,  S. Heilmann-Heimbach,  K. H. Jöckel,  M. Greaves,  C. J. Harrison,  C. R. Bartram,  M. Schrappe,  M. Stanulla,  K. Hemminki,  R. S. Houlston.

Leukemia
Volume: 31, Issue: 3, Pages: 573-579.

APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL

Z. Li,  B. J. Abraham,  A. Berezovskaya,  N. Farah,  Y. Liu,  T. Leon,  A. Fielding,  S. H. Tan,  T. Sanda,  A. S. Weintraub,  B. Li,  S. Shen,  J. Zhang,  M. R. Mansour,  R. A. Young,  A. T. Look.

Leukemia
Volume: 31, Issue: 10, Pages: 2057-2064.

Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia

Viktoras Frismantas,  Maria Pamela Dobay,  Anna Rinaldi,  Joelle Tchinda,  Samuel H. Dunn,  Joachim Kunz,  Paulina Richter-Pechanska,  Blerim Marovca,  Orrin Pail,  Silvia Jenni,  Ernesto Diaz-Flores,  Bill H. Chang,  Timothy J. Brown,  Robert H. Collins,  Sebastian Uhrig,  Gnana P. Balasubramanian,  Obul R. Bandapalli,  Salome Higi,  Sabrina Eugster,  Pamela Voegeli,  Mauro Delorenzi,  Gunnar Cario,  Mignon L. Loh,  Martin Schrappe,  Martin Stanulla,  Andreas E. Kulozik,  Martina U. Muckenthaler,  Vaskar Saha,  Julie A. Irving,  Roland Meisel,  Thomas Radimerski,  Arend Von Stackelberg,  Cornelia Eckert,  Jeffrey W. Tyner,  Peter Horvath,  Beat C. Bornhauser,  Jean-Pierre Bourquin.

Blood
Volume: 129, Issue: 11, Pages: e26-e37.

Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia

Lisa J. Russell,  Lisa Jones,  Amir Enshaei,  Stefano Tonin,  Sarra L. Ryan,  Jeyanthy Eswaran,  Sirintra Nakjang,  Elli Papaemmanuil,  Jose M. C. Tubio,  Adele K. Fielding,  Ajay Vora,  Peter J. Campbell,  Anthony V. Moorman,  Christine J. Harrison.

Genes, Chromosomes & Cancer
Volume: 56, Issue: 5, Pages: 363-372.

Targeting the 5T4 oncofetal glycoprotein with an antibody drug conjugate (A1mcMMAF) improves survival in patient-derived xenograft models of acute lymphoblastic leukemia

Owen J. McGinn,  Shekhar Krishnan,  Jean-Pierre Bourquin,  Puja Sapra,  Clare Dempsey,  Vaskar Saha,  Peter L. Stern.

Haematologica
Volume: 102, Issue: 6, Pages: 1075-1084.

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

Antonis Dagklis,  Sofie Demeyer,  Jolien De Bie,  Enrico Radaelli,  Daphnie Pauwels,  Sandrine Degryse,  Olga Gielen,  Carmen Vicente,  Roel Vandepoel,  Ellen Geerdens,  Anne Uyttebroeck,  Nancy Boeckx,  Charles E. de Bock,  Jan Cools.

Blood
Volume: 128, Issue: 23, Pages: 2642-2654.

Genomic Landscape of Pediatric Mixed Phenotype Acute Leukemia

Thomas B. Alexander,  Zhaohui Gu,  John K. Choi,  Mignon L. Loh,  John Horan,  Barbara Buldini,  Giuseppe Basso,  Sarah Elitzur,  C. Michel Zwaan,  Valerie de Haas,  Allen Eng Juh Yeoh,  Dirk Reinhardt,  Daisuke Tomizawa,  Tim Lammens,  Barbara De Moerloose,  Li Zhou,  Hiroki Hori,  Anthony V. Moorman,  Andrew S. Moore,  Ondrej Hrusak,  Soheil Meshinchi,  Etan Orgel,  Meenakshi Devidas,  Stephen P. Hunger,  Jamie M. Guidry Auvil,  Malcolm A. Smith,  Tanja M. Davidsen,  Leandro C. Hermida,  Patee Gesuwan,  Marco A. Marra,  Yussanne Ma,  Andrew J. Mungall,  Richard Moore,  Daniela S. Gerhard,  Xueyuan Cao,  Lei Shi,  Stanley Pounds,  Hiroto Inaba,  Charles Mullighan.

Blood
Volume: 128, Issue: 22, Pages: 454-454.

High Resolution Igh Repertoire Analysis Reveals the Human Fetal Liver As the Origin of Life-Long, Innate B Lymphopoiesis

Anindita Roy,  Vojtech Bystry,  Georg Bohn,  Katerina Goudevenou,  Tomas Reigl,  Maria Papaioannou,  Adam Krejci,  Sorcha O'Byrne,  Aristeidis Chaidos,  Andrea Grioni,  Nikos Darzentas,  Irene Roberts,  Anastasios Karadimitris.

Blood
Volume: 128, Issue: 22, Pages: 127-127.

The Frequency and Outcome of Ph-like ALL Associated Abnormalities in Childhood Acute Lymphoblastic Leukaemia Treated on MRC UKALL2003

Claire Schwab,  Amir Enshaei,  Kathryn G. Roberts,  Lisa J. Russell,  Richard C. Harvey,  I.-Ming L. Chen,  Cheryl L. Willman,  Charles Mullighan,  Ajay J. Vora,  Anthony V. Moorman,  Christine Harrison.

Blood
Volume: 128, Issue: 22, Pages: 2914-2914.

Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids

Anindita Dutta,  David N. Potier,  Michael J. Walker,  Oliver J. Gray,  Catriona Parker,  Mark Holland,  Andrew J. K. Williamson,  Andrew Pierce,  Richard D. Unwin,  Shekhar Krishnan,  Vaskar Saha,  Anthony D. Whetton.

Oncotarget
Volume: 7, Issue: 43, Pages: 70822-70831.

Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia

Julie A. E. Irving,  Amir Enshaei,  Catriona A. Parker,  Rosemary Sutton,  Roland P. Kuiper,  Amy Erhorn,  Lynne Minto,  Nicola C. Venn,  Tamara Law,  Jiangyan Yu,  Claire Schwab,  Rosanna Davies,  Elizabeth Matheson,  Alysia Davies,  Edwin Sonneveld,  Monique L. den Boer,  Sharon B. Love,  Christine J. Harrison,  Peter M. Hoogerbrugge,  Tamas Revesz,  Vaskar Saha,  Anthony V. Moorman.

Blood
Volume: 128, Issue: 7, Pages: 911-922.

Genome wide dysregulation of gene expression by trisomy 20 in fetal liver haematopoietic stem and progenitor cells.

Roy, Anindita,  Liu, Binbin,  Goudevenou, Katerina,  Bohn, Georg,  Filippi, Sarah,  Elliott, Natalina,  Cowan, Gillian,  O'Connor, David,  Bhatnagar, Neha,  Karadimitris, Anastasios,  Roberts, Irene.

Haematologica
Volume: 101, Issue: S1, Pages: 1-881.

Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differeation pathways

Psaila, Bethan,  Barkas, Nikolaos,  Iskander, Deena,  Roy, Anindita,  Anderson, Stacie,  Ashley, Neil,  Caputo, Valentina,  Lichtenberg, Jens,  Loaiza, Sandra,  Bodine, David,  Karadimitris, Anastasios,  Mead, Adam,  Roberts, Irene.

Haematologica
Volume: 101, Issue: S1, Pages: 1-881.

Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways

Bethan Psaila,  Nikolaos Barkas,  Deena Iskander,  Anindita Roy,  Stacie Anderson,  Neil Ashley,  Valentina S. Caputo,  Jens Lichtenberg,  Sandra Loaiza,  David M. Bodine,  Anastasios Karadimitris,  Adam J. Mead,  Irene Roberts.

Genome Biology
Volume: 17, Pages: 83.

The ability to cross the blood–cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts

Mark T. S. Williams,  Yasar M. Yousafzai,  Alex Elder,  Klaus Rehe,  Simon Bomken,  Liron Frishman-Levy,  Sigal Tavor,  Paul Sinclair,  Katie Dormon,  Dino Masic,  Tracey Perry,  Victoria J. Weston,  Pamela Kearns,  Helen Blair,  Lisa J. Russell,  Olaf Heidenreich,  Julie A. E. Irving,  Shai Izraeli,  Josef Vormoor,  Gerard J. Graham,  Christina Halsey.

Blood
Volume: 127, Issue: 16, Pages: 1998-2006.

Constitutional abnormalities of chromosome 21 predispose to iAMP21-acute lymphoblastic leukaemia

Christine J. Harrison,  Claire Schwab.

European Journal of Medical Genetics
Volume: 59, Issue: 3, Pages: 162-165.

Prognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative study

J. M. Boer,  A. van der Veer,  D. Rizopoulos,  M. Fiocco,  E. Sonneveld,  H. A. de Groot-Kruseman,  R. P. Kuiper,  P. Hoogerbrugge,  M. Horstmann,  M. Zaliova,  C. Palmi,  J. Trka,  E. Fronkova,  M. Emerenciano,  M. do Socorro Pombo-de-Oliveira,  W. Mlynarski,  T. Szczepanski,  K. Nebral,  A. Attarbaschi,  N. Venn,  R. Sutton,  C. J. Schwab,  A. Enshaei,  A. Vora,  M. Stanulla,  M. Schrappe,  G. Cazzaniga,  V. Conter,  M. Zimmermann,  A. V. Moorman,  R. Pieters,  M. L. den Boer.

Leukemia
Volume: 30, Issue: 1, Pages: 32-38.

EBF1-PDGFRB fusion in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL): genetic profile and clinical implications

Claire Schwab,  Sarra L. Ryan,  Lucy Chilton,  Alannah Elliott,  James Murray,  Stacey Richardson,  Christopher Wragg,  John Moppett,  Michelle Cummins,  Oliver Tunstall,  Catriona A. Parker,  Vaskar Saha,  Nicholas Goulden,  Ajay Vora,  Anthony V. Moorman,  Christine J. Harrison.

Blood
Volume: 127, Issue: 18, Pages: 2214-2218.

Metabolic reprogramming of bone marrow stromal cells by leukemic extracellular vesicles in acute lymphoblastic leukemia

Suzanne M. Johnson,  Clare Dempsey,  Amy Chadwick,  Stephanie Harrison,  Jizhong Liu,  Yujun Di,  Owen J. McGinn,  Marco Fiorillo,  Federica Sotgia,  Michael P. Lisanti,  Mayur Parihar,  Shekhar Krishnan,  Vaskar Saha.

Blood
Volume: 128, Issue: 3, Pages: 453-456.

Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia

Roberta La Starza,  Gianluca Barba,  Sofie Demeyer,  Valentina Pierini,  Danika Di Giacomo,  Valentina Gianfelici,  Claire Schwab,  Caterina Matteucci,  Carmen Vicente,  Jan Cools,  Monica Messina,  Barbara Crescenzi,  Sabina Chiaretti,  Robin Foà,  Giuseppe Basso,  Christine J. Harrison,  Cristina Mecucci.

Haematologica
Volume: 101, Issue: 8, Pages: 951-958.

The role of the RAS pathway in iAMP21-ALL

S. L. Ryan,  E. Matheson,  V. Grossmann,  P. Sinclair,  M. Bashton,  C. Schwab,  W. Towers,  M. Partington,  A. Elliott,  L. Minto,  S. Richardson,  T. Rahman,  B. Keavney,  R. Skinner,  N. Bown,  T. Haferlach,  P. Vandenberghe,  C. Haferlach,  M. Santibanez-Koref,  A. V. Moorman,  A. Kohlmann,  J. a. E. Irving,  C. J. Harrison.

Leukemia
Volume: 30, Issue: 9, Pages: 1824-1831.

Characterization of leukemias with ETV6-ABL1 fusion

Marketa Zaliova,  Anthony V. Moorman,  Giovanni Cazzaniga,  Martin Stanulla,  Richard C. Harvey,  Kathryn G. Roberts,  Sue L. Heatley,  Mignon L. Loh,  Marina Konopleva,  I.-Ming Chen,  Olga Zimmermannova,  Claire Schwab,  Owen Smith,  Marie-Joelle Mozziconacci,  Christian Chabannon,  Myungshin Kim,  J. H. Frederik Falkenburg,  Alice Norton,  Karen Marshall,  Oskar A. Haas,  Julia Starkova,  Jan Stuchly,  Stephen P. Hunger,  Deborah White,  Charles G. Mullighan,  Cheryl L. Willman,  Jan Stary,  Jan Trka,  Jan Zuna.

Haematologica
Volume: 101, Issue: 9, Pages: 1082-1093.

The 9p21.3 risk of childhood acute lymphoblastic leukaemia is explained by a rare high-impact variant in CDKN2A

Jayaram Vijayakrishnan,  Marc Henrion,  Anthony V. Moorman,  Bettina Fiege,  Rajiv Kumar,  Miguel Inacio da Silva Filho,  Amy Holroyd,  Rolf Koehler,  Hauke Thomsen,  Julie A. Irving,  James M. Allan,  Tracy Lightfoot,  Eve Roman,  Sally E. Kinsey,  Eamonn Sheridan,  Pamela D. Thompson,  Per Hoffmann,  Markus M. Nöthen,  Thomas W. Mühleisen,  Lewin Eisele,  Claus R. Bartram,  Martin Schrappe,  Mel Greaves,  Kari Hemminki,  Christine J. Harrison,  Martin Stanulla,  Richard S. Houlston.

Scientific Reports
Volume: 5, Pages: 15065.

Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia

Carmen Vicente,  Claire Schwab,  Michaël Broux,  Ellen Geerdens,  Sandrine Degryse,  Sofie Demeyer,  Idoya Lahortiga,  Alannah Elliott,  Lucy Chilton,  Roberta La Starza,  Cristina Mecucci,  Peter Vandenberghe,  Nicholas Goulden,  Ajay Vora,  Anthony V. Moorman,  Jean Soulier,  Christine J. Harrison,  Emmanuelle Clappier,  Jan Cools.

Haematologica
Volume: 100, Issue: 10, Pages: 1301-1310.

Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia

Carmen Vicente,  Claire Schwab,  Michaël Broux,  Ellen Geerdens,  Sandrine Degryse,  Sofie Demeyer,  Idoya Lahortiga,  Alannah Elliott,  Lucy Chilton,  Roberta La Starza,  Cristina Mecucci,  Peter Vandenberghe,  Nicholas Goulden,  Ajay Vora,  Anthony V. Moorman,  Jean Soulier,  Christine J. Harrison,  Emmanuelle Clappier,  Jan Cools.

Haematologica
Volume: 100, Issue: 10, Pages: 1301-1310.

Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia

C. Michel Zwaan,  Edward A. Kolb,  Dirk Reinhardt,  Jonas Abrahamsson,  Souichi Adachi,  Richard Aplenc,  Eveline S.J.M. De Bont,  Barbara De Moerloose,  Michael Dworzak,  Brenda E.S. Gibson,  Henrik Hasle,  Guy Leverger,  Franco Locatelli,  Christine Ragu,  Raul C. Ribeiro,  Carmelo Rizzari,  Jeffrey E. Rubnitz,  Owen P. Smith,  Lillian Sung,  Daisuke Tomizawa,  Marry M. van den Heuvel-Eibrink,  Ursula Creutzig,  Gertjan J.L. Kaspers.

Journal of Clinical Oncology
Volume: 33, Issue: 27, Pages: 2949-2962.

MLL-AF4 perturbs the self-renewal and differentiation potential of HSC during the definitive wave of haematopoiesis: A stage-specific pattern

Camille Malouf,  Chrysa Kapeni,  Katrin Ottersbach.

Experimental Hematology
Volume: 43, Issue: 9, Pages: S78.

Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options

Ute Fischer,  Michael Forster,  Anna Rinaldi,  Thomas Risch,  Stéphanie Sungalee,  Hans-Jörg Warnatz,  Beat Bornhauser,  Michael Gombert,  Christina Kratsch,  Adrian M. Stütz,  Marc Sultan,  Joelle Tchinda,  Catherine L. Worth,  Vyacheslav Amstislavskiy,  Nandini Badarinarayan,  André Baruchel,  Thies Bartram,  Giuseppe Basso,  Cengiz Canpolat,  Gunnar Cario,  Hélène Cavé,  Dardane Dakaj,  Mauro Delorenzi,  Maria Pamela Dobay,  Cornelia Eckert,  Eva Ellinghaus,  Sabrina Eugster,  Viktoras Frismantas,  Sebastian Ginzel,  Oskar A. Haas,  Olaf Heidenreich,  Georg Hemmrich-Stanisak,  Kebria Hezaveh,  Jessica I. Höll,  Sabine Hornhardt,  Peter Husemann,  Priyadarshini Kachroo,  Christian P. Kratz,  Geertruy Te Kronnie,  Blerim Marovca,  Felix Niggli,  Alice C. McHardy,  Anthony V. Moorman,  Renate Panzer-Grümayer,  Britt S. Petersen,  Benjamin Raeder,  Meryem Ralser,  Philip Rosenstiel,  Daniel Schäfer,  Martin Schrappe,  Stefan Schreiber,  Moritz Schütte,  Björn Stade,  Ralf Thiele,  Nicolas von der Weid,  Ajay Vora,  Marketa Zaliova,  Langhui Zhang,  Thomas Zichner,  Martin Zimmermann,  Hans Lehrach,  Arndt Borkhardt,  Jean-Pierre Bourquin,  Andre Franke,  Jan O. Korbel,  Martin Stanulla,  Marie-Laure Yaspo.

Nature Genetics
Volume: 47, Issue: 9, Pages: 1020-1029.

Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia

Alem S. Gabriel,  Fadhel M. Lafta,  Edward C. Schwalbe,  Sirintra Nakjang,  Simon J. Cockell,  Alice Iliasova,  Amir Enshaei,  Claire Schwab,  Vikki Rand,  Steven C. Clifford,  Sally E. Kinsey,  Chris D. Mitchell,  Ajay Vora,  Christine J. Harrison,  Anthony V. Moorman,  Gordon Strathdee.

Epigenetics
Volume: 10, Issue: 8, Pages: 717-726.

Frequent infection of human cancer xenografts with murine endogenous retroviruses in vivo

Asif Naseer,  Anne Terry,  Kathryn Gilroy,  Anna Kilbey,  Ciorsdaidh Watts,  Nancy Mackay,  Margaret Bell,  Susan Mason,  Karen Blyth,  Ewan Cameron,  James C. Neil.

Viruses
Volume: 7, Issue: 4, Pages: 2014-2029.

Clonal origins of ETV6-RUNX1(+) acute lymphoblastic leukemia: studies in monozygotic twins

D. Alpar,  D. Wren,  L. Ermini,  M. B. Mansur,  F. W. van Delft,  C. M. Bateman,  I. Titley,  L. Kearney,  T. Szczepanski,  D. G. de Castro,  A. M. Ford,  N. E. Potter,  M. Greaves.

Leukemia
Volume: 29, Pages: 839-846.

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Steven Goossens,  Enrico Radaelli,  Odile Blanchet,  Kaat Durinck,  Joni Van der Meulen,  Sofie Peirs,  Tom Taghon,  Cedric S. Tremblay,  Magdaline Costa,  Morvarid Farhang Ghahremani,  Jelle De Medts,  Sonia Bartunkova,  Katharina Haigh,  Claire Schwab,  Natalie Farla,  Tim Pieters,  Filip Matthijssens,  Nadine Van Roy,  J. Adam Best,  Kim Deswarte,  Pieter Bogaert,  Catherine Carmichael,  Adam Rickard,  Santi Suryani,  Lauryn S. Bracken,  Raed Alserihi,  Kirsten Canté-Barrett,  Lieven Haenebalcke,  Emmanuelle Clappier,  Pieter Rondou,  Karolina Slowicka,  Danny Huylebroeck,  Ananda W. Goldrath,  Viktor Janzen,  Matthew P. McCormack,  Richard B. Lock,  David J. Curtis,  Christine Harrison,  Geert Berx,  Frank Speleman,  Jules P. P. Meijerink,  Jean Soulier,  Pieter Van Vlierberghe,  Jody J. Haigh.

Nature Communications
Volume: 6, Pages: 5794.

Evolutionary trajectories of hyperdiploid ALL in monozygotic twins

C. M. Bateman,  D. Alpar,  A. M. Ford,  S. M. Colman,  D. Wren,  M. Morgan,  L. Kearney,  M. Greaves.

Leukemia
Volume: 29, Issue: 1, Pages: 58-65.

Stem and progenitor cell dysfunction in human trisomies

Binbin Liu,  Sarah Filippi,  Anindita Roy,  Irene Roberts.

EMBO reports
Volume: 16, Issue: 1, Pages: 44-62.

Childhood pre-B acute lymphoblastic leukaemia cells capable of central nervous system engraftment are common, heterogeneous and transit the blood-cerebrospinal fluid barrier

Y. M. Yousafzai,  M. T. S. Williams,  S. Bhatti,  A. Cousins,  K. Rehe,  S. Bomken,  P. Sinclair,  V. J. Weston,  L. J. Russell,  O. Heidenreich,  others.

BRITISH JOURNAL OF HAEMATOLOGY
Volume: 169, Pages: 17–17.

Clinical and Hematologic Impact of Fetal and Perinatal Variables on Mutant GATA1 Clone Size in Neonates with Down Syndrome

Neha Bhatnagar,  Kelly Perkins,  Sarah Filippi,  Helen Richmond,  Joanna Bonnici,  Kate Alford,  Georgina Hall,  Gaëtan Juban,  Simon McGowan,  Anindita Roy,  Natalina Elliott,  Michael Stumpf,  Alice Norton,  Paresh Vyas,  Irene Roberts.

Blood
Volume: 124, Issue: 21, Pages: 2349-2349.

No Evidence That PTEN Abnormalities Impact on Outcome in Pediatric Patients with T-Cell Acute Lymphoblastic Leukemia (T-ALL) Treated on the MRC UKALL2003 Trial

Sarah Jenkinson,  Amy A. Kirkwood,  Nicholas Goulden,  Ajay J. Vora,  Chris Mitchell,  Rachel Wade,  Jeremy Hancock,  Anthony V. Moorman,  David C. Linch,  Rosemary E. Gale.

Blood
Volume: 124, Issue: 21, Pages: 1077-1077.

The Sub-Clonal Complexity of STIL-TAL1 T-ALL

Caroline L. Furness,  Marcela B. Mansur,  Victoria J. Weston,  Sarah Jenkinson,  Frederik W. van Delft,  Lyndal Kearney,  Ian Titley,  Anthony M. Ford,  Rosemary E. Gale,  Pamela R. Kearns,  Adolfo A. Ferrando,  Christine J. Harrison,  Nicola E. Potter,  Mel Greaves.

Blood
Volume: 124, Issue: 21, Pages: 3788-3788.

Trisomy 21-Associated Abnormalities in IGF Signalling and the Fetal Microenvironment Both Contribute to Disruption of Fetal Hematopoiesis in Down Syndrome

David O'Connor,  Binbin Liu,  Gillian Cowan,  Anindita Roy,  Katerina Goudevenou,  Neha Bhatnagar,  Oliver Tunstall,  Josu de la Fuente,  Anastasios Karadimitris,  Irene Roberts.

Blood
Volume: 124, Issue: 21, Pages: 1885-1885.

EBF1-PDGFR? Fusion in Paediatric Acute Lymphoblastic Leukaemia (ALL): Genetic Profile and Clinical Implications

Claire Schwab,  Rebecca Andrews,  Lucy Chilton,  Alannah Elliott,  Gerald Keil,  Stacey Richardson,  Sarra L. Ryan,  Christopher Wragg,  John Moppett,  Michelle Cummins,  Nicholas Goulden,  Ajay J. Vora,  Anthony V. Moorman,  Christine J. Harrison.

Blood
Volume: 124, Issue: 21, Pages: 1068-1068.

Developmental Stage Specific B-Progenitor Expansion in Normal Fetal Bone Marrow Is Absent in Down Syndrome: Implications for Infant ALL

Anindita Roy,  Georg Bohn,  Katerina Goudevenou,  Gillian Cowan,  Neha Bhatnagar,  David O'Connor,  Oliver Tunstall,  Jerry Chan,  Phillip Bennett,  Sailesh Kumar,  Deena Iskander,  Sarah Inglott,  Binbin Liu,  Philip Ancliff,  Anastasios Karadimitris,  Irene Roberts.

Blood
Volume: 124, Issue: 21, Pages: 4331-4331.

SSBP2-CSF1R Is a Recurrent Fusion in B-Other Acute Lymphoblastic Leukaemia with Variable Clinical Outcome

Claire Schwab,  Rebecca Andrews,  Lucy Chilton,  Alannah Elliott,  Stacey Richardson,  Sarra L. Ryan,  Amy Logan,  Adele K. Fielding,  Nicholas Goulden,  Ajay J. Vora,  Anthony V. Moorman,  Christine A. Macartney,  Christine J. Harrison.

Blood
Volume: 124, Issue: 21, Pages: 3773-3773.

Genetic profile of T-cell acute lymphoblastic leukemias with MYC translocations

Roberta La Starza,  Chiara Borga,  Gianluca Barba,  Valentina Pierini,  Claire Schwab,  Caterina Matteucci,  Anair G. Lema Fernandez,  Anna Leszl,  Gianni Cazzaniga,  Sabina Chiaretti,  Giuseppe Basso,  Christine J. Harrison,  Geertruy Te Kronnie,  Cristina Mecucci.

Blood
Volume: 124, Issue: 24, Pages: 3577-3582.

A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia

Anthony V. Moorman,  Amir Enshaei,  Claire Schwab,  Rachel Wade,  Lucy Chilton,  Alannah Elliott,  Stacey Richardson,  Jeremy Hancock,  Sally E. Kinsey,  Christopher D. Mitchell,  Nicholas Goulden,  Ajay Vora,  Christine J. Harrison.

Blood
Volume: 124, Issue: 9, Pages: 1434-1444.

Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003

Katharine Patrick,  Rachel Wade,  Nick Goulden,  Chris Mitchell,  Anthony V. Moorman,  Clare Rowntree,  Sarah Jenkinson,  Rachael Hough,  Ajay Vora.

British Journal of Haematology
Volume: 166, Issue: 3, Pages: 421-424.

Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia

Mark T. S. Williams,  Yasar Yousafzai,  Charlotte Cox,  Allison Blair,  Ruaidhrí Carmody,  Shuji Sai,  Karen E. Chapman,  Rachel McAndrew,  Angela Thomas,  Alison Spence,  Brenda Gibson,  Gerard J. Graham,  Christina Halsey.

Blood
Volume: 123, Issue: 20, Pages: 3116-3127.

IGH@ translocations are prevalent in teenagers and young adults with acute lymphoblastic leukemia and are associated with a poor outcome

Lisa J. Russell,  Amir Enshaei,  Lisa Jones,  Amy Erhorn,  Dino Masic,  Helen Bentley,  Karl S. Laczko,  Adele K. Fielding,  Anthony H. Goldstone,  Nicholas Goulden,  Christopher D. Mitchell,  Rachel Wade,  Ajay Vora,  Anthony V. Moorman,  Christine J. Harrison.

Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Volume: 32, Issue: 14, Pages: 1453-1462.

Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol

Katharine Patrick,  Rachel Wade,  Nicholas Goulden,  Clare Rowntree,  Rachael Hough,  Anthony V. Moorman,  Christopher D. Mitchell,  Ajay Vora.

British Journal of Haematology
Volume: 165, Issue: 4, Pages: 552-555.

An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome

C. J. Harrison,  A. V. Moorman,  C. Schwab,  A. J. Carroll,  E. A. Raetz,  M. Devidas,  S. Strehl,  K. Nebral,  J. Harbott,  A. Teigler-Schlegel,  M. Zimmerman,  N. Dastuge,  A. Baruchel,  J. Soulier,  M.-F. Auclerc,  A. Attarbaschi,  G. Mann,  B. Stark,  G. Cazzaniga,  L. Chilton,  P. Vandenberghe,  E. Forestier,  I. Haltrich,  S. C. Raimondi,  M. Parihar,  J.-P. Bourquin,  J. Tchinda,  C. Haferlach,  A. Vora,  S. P. Hunger,  N. A. Heerema,  O. A. Haas,  Ponte di Legno International Workshop in Childhood Acute Lymphoblastic Leukemia.

Leukemia
Volume: 28, Issue: 5, Pages: 1015-1021.

The optimal use of PEG-asparaginase in relapsed ALL--lessons from the ALLR3 Clinical Trial

A. Masurekar,  C. Fong,  A. Hussein,  T. Revesz,  P. M. Hoogerbrugge,  S. Love,  C. Ciria,  C. Parker,  S. Krishnan,  V. Saha.

Blood Cancer Journal
Volume: 4, Pages: e203.

Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia

Yilong Li,  Claire Schwab,  Sarra L. Ryan,  Elli Papaemmanuil,  Hazel M. Robinson,  Patricia Jacobs,  Anthony V. Moorman,  Sara Dyer,  Julian Borrow,  Mike Griffiths,  Nyla A. Heerema,  Andrew J. Carroll,  Polly Talley,  Nick Bown,  Nick Telford,  Fiona M. Ross,  Lorraine Gaunt,  Richard J. Q. McNally,  Bryan D. Young,  Paul Sinclair,  Vikki Rand,  Manuel R. Teixeira,  Olivia Joseph,  Ben Robinson,  Mark Maddison,  Nicole Dastugue,  Peter Vandenberghe,  Claudia Haferlach,  Philip J. Stephens,  Jiqiu Cheng,  Peter Van Loo,  Michael R. Stratton,  Peter J. Campbell,  Christine J. Harrison.

Nature
Volume: 508, Issue: 7494, Pages: 98-102.

Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis

Camille A. Huser,  Kathryn L. Gilroy,  Jeroen de Ridder,  Anna Kilbey,  Gillian Borland,  Nancy Mackay,  Alma Jenkins,  Margaret Bell,  Pawel Herzyk,  Louise van der Weyden,  David J. Adams,  Alistair G. Rust,  Ewan Cameron,  James C. Neil.

PLoS genetics
Volume: 10, Issue: 2, Pages: e1004167.

An Analysis Of Mechanisms Of Central Nervous System Infiltration In Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice

Yasar Yousafzai,  Mark TS Williams,  Klaus Rehe,  Michelle Le Brocq,  Simon Bomken,  Paul B. Sinclair,  Katie Dormon,  Dino Masic,  Leanne Archer,  Jennifer Watt,  Tracey A. Perry,  Victoria J. Weston,  Pamela R. Kearns,  Helen Blair,  Russel Lisa,  Olaf Heidenreich,  Julie Irving,  Josef Vormoor,  Brenda Gibson,  Gerard J. Graham,  Christina Halsey.

Blood
Volume: 122, Issue: 21, Pages: 3866-3866.

Clonal Evolution and Sub-Clonal Architecture In Paediatric T-Cell Acute Lymphoblastic Leukaemia (T-ALL)

Furness, Caroline,  Marcela B. Mansur,  Victoria J. Weston,  Frederik W. Van Delft,  Lyndal Kearney,  Christine J. Harrison,  Anthony M. Ford,  Pamela R. Kearns,  Nicola E. Potter,  Jean Soulier,  Adolfo A. Ferrando,  Mel Greaves.

Blood
Volume: 122, Issue: 21, Pages: 1366-1366.

Integration Of Cytogenetic and Copy Number Alteration (CNA) Data Into a Single Risk Profile For Paediatric Acute Lymphoblastic Leukaemia (ALL)

A V Moorman,  Amir Enshaei,  Claire Schwab,  Lucy Chilton,  Rachel Wade,  Nicholas Goulden,  Ajay J. Vora,  Christine J. Harrison.

Blood
Volume: 122, Issue: 21, Pages: 1308-1308.

Long-term follow-up of ETV6-RUNX1 ALL reveals that NCI risk, rather than secondary genetic abnormalities, is the key risk factor

A. Enshaei,  C. J. Schwab,  Z. J. Konn,  C. D. Mitchell,  S. E. Kinsey,  R. Wade,  A. Vora,  C. J. Harrison,  A. V. Moorman.

Leukemia
Volume: 27, Issue: 11, Pages: 2256-2259.

Risk-directed treatment intensification significantly reduces the risk of relapse among children and adolescents with acute lymphoblastic leukemia and intrachromosomal amplification of chromosome 21: a comparison of the MRC ALL97/99 and UKALL2003 trials

Anthony V. Moorman,  Hazel Robinson,  Claire Schwab,  Sue M. Richards,  Jeremy Hancock,  Christopher D. Mitchell,  Nicholas Goulden,  Ajay Vora,  Christine J. Harrison.

Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Volume: 31, Issue: 27, Pages: 3389-3396.

Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features

Claire J. Schwab,  Lucy Chilton,  Heather Morrison,  Lisa Jones,  Halima Al-Shehhi,  Amy Erhorn,  Lisa J. Russell,  Anthony V. Moorman,  Christine J. Harrison.

Haematologica
Volume: 98, Issue: 7, Pages: 1081-1088.

Treatment reduction for children and young adults with low-risk acute lymphoblastic leukaemia defined by minimal residual disease (UKALL 2003): a randomised controlled trial

Ajay Vora,  Nick Goulden,  Rachel Wade,  Chris Mitchell,  Jeremy Hancock,  Rachael Hough,  Clare Rowntree,  Sue Richards.

The Lancet Oncology
Volume: 14, Issue: 3, Pages: 199-209.

Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia

Halima Al-Shehhi,  Zoe J. Konn,  Claire J. Schwab,  Amy Erhorn,  Kerry E. Barber,  Sarah L. Wright,  Alem S. Gabriel,  Christine J. Harrison,  Anthony V. Moorman.

Genes, Chromosomes & Cancer
Volume: 52, Issue: 2, Pages: 202-213.

BTG1 deletions do not predict outcome in Down syndrome acute lymphoblastic leukemia

T. D. Buitenkamp,  R. Pieters,  M. Zimmermann,  V. de Haas,  S. M. Richards,  A. J. Vora,  C. D. Mitchell,  C. Schwab,  C. J. Harrison,  A. V. Moorman,  M. M. van den Heuvel-Eibrink,  C. M. Zwaan.

Leukemia
Volume: 27, Issue: 1, Pages: 251-252.

Impact of NOTCH1/FBXW7 mutations on outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on the MRC UKALL 2003 trial

S. Jenkinson,  K. Koo,  M. R. Mansour,  N. Goulden,  A. Vora,  C. Mitchell,  R. Wade,  S. Richards,  J. Hancock,  A. V. Moorman,  D. C. Linch,  R. E. Gale.

Leukemia
Volume: 27, Issue: 1, Pages: 41-47.

IKZF1 and 22q11.22 Deletions and PDGFRA Gains Are Associated with Poor Outcome in Down Syndrome Acute Lymphoblastic Leukemia

Karen R. Rabin,  Clinton C. Mason,  Sivashankarappa Gurusiddappa,  Hon-Chiu Eastwood Leung,  Debra J. Morrison,  Deepa Bhojwani,  Phillip Barnette,  Sarah T. South,  Rodney R. Miles,  Meenakshi Devidas,  Andrea Pession,  Giuseppe Basso,  Nicola E. Potter,  Lyndal Kearney,  Anthony V. Moorman,  Susana C. Raimondi,  Sima Jeha,  Ching-Hon Pui,  William L. Carroll,  Mignon L. Loh,  Stephen P. Hunger,  Charles G. Mullighan,  Joshua D. Schiffman.

Blood
Volume: 120, Issue: 21, Pages: 289-289.

Clinical Relevance of Genes Commonly Deleted in Childhood B-Cell Precursor ALL (BCP-ALL)

Claire Schwab,  Lucy Chilton,  Amir Enshaie,  Heather Morrison,  Lisa Jones,  Halima A. Al-Shehhi,  Amy Erhorn,  Lisa J. Russell,  Ajay J. Vora,  Christopher D. Mitchell,  Sue M. Richards,  Nicholas Goulden,  Sally Kinsey,  Anthony V. Moorman,  Christine J. Harrison.

Blood
Volume: 120, Issue: 21, Pages: 290-290.

Genes Commonly Deleted in Childhood B-Cell Precursor ALL (BCP-ALL) Are Associated with Major Cytogenetic Subgroups

Claire Schwab,  Lucy Chilton,  Heather Morrison,  Lisa Jones,  Halima A. Al-Shehhi,  Amy Erhorn,  Lisa J. Russell,  Anthony V. Moorman,  Christine J. Harrison.

Blood
Volume: 120, Issue: 21, Pages: 1374-1374.

Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations

T. D. Buitenkamp,  R. Pieters,  N. E. Gallimore,  A. van der Veer,  J. P. P. Meijerink,  H. B. Beverloo,  M. Zimmermann,  V. de Haas,  S. M. Richards,  A. J. Vora,  C. D. Mitchell,  L. J. Russell,  C. Schwab,  C. J. Harrison,  A. V. Moorman,  M. M. van den Heuvel-Eibrink,  M. L. den Boer,  C. M. Zwaan.

Leukemia
Volume: 26, Issue: 10, Pages: 2204-2211.

Analysis of Rho GTPase expression in T-ALL identifies RhoU as a target for Notch involved in T-ALL cell migration

P J Bhavsar,  E Infante,  A Khwaja,  A J Ridley.

Oncogene
Volume: 32, Pages: 198-208.

Polymorphism in the PAI-1 (SERPINE1) gene and the risk of osteonecrosis in children with acute lymphoblastic leukemia

Jonathan Bond,  Stuart Adams,  Susan Richards,  Ajay Vora,  Christopher Mitchell,  Nicholas Goulden.

Blood
Volume: 118, Issue: 9, Pages: 2632-2633.

Analysis of a breakpoint cluster reveals insight into the mechanism of intrachromosomal amplification in a lymphoid malignancy

Paul B Sinclair,  Helen Parker,  Qian An,  Vikki Rand,  Hannah Ensor,  Christine J Harrison,  Jonathan C Strefford.

Human molecular genetics
Volume: 20, Issue: 13, Pages: 2591-2602.

Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia

Vikki Rand,  Helen Parker,  Lisa J Russell,  Claire Schwab,  Hannah Ensor,  Julie Irving,  Lisa Jones,  Dino Masic,  Lynne Minto,  Heather Morrison,  Sarra Ryan,  Hazel Robinson,  Paul Sinclair,  Anthony V Moorman,  Jonathan C Strefford,  Christine J Harrison.

Blood
Volume: 117, Issue: 25, Pages: 6848-6855.

Biology, Risk Stratification, and Therapy of Pediatric Acute Leukemias: An Update

Ching-Hon Pui,  William L. Carroll,  Soheil Meshinchi,  Robert J. Arceci.

Journal of Clinical Oncology
Volume: 29, Issue: 5, Pages: 551-565.

Results of a randomized trial in children with Acute Myeloid Leukaemia: Medical Research Council AML12 trial

Brenda E. S. Gibson,  David K. H. Webb,  Andrew J. Howman,  Siebold S. N. De Graaf,  Christine J. Harrison,  Keith Wheatley.

British Journal of Haematology
Volume: 155, Issue: 3, Pages: 366-376.

Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial

Catriona Parker,  Rachel Waters,  Carly Leighton,  Jeremy Hancock,  Rosemary Sutton,  Anthony V Moorman,  Philip Ancliff,  Mary Morgan,  Ashish Masurekar,  Nicholas Goulden,  Nina Green,  Tamas Révész,  Philip Darbyshire,  Sharon Love,  Vaskar Saha.

Lancet
Volume: 376, Issue: 9757, Pages: 2009-2017.

Evolutionary trajectory of hyperdiploid ALL: Insights from monozygotic twins.

Bateman, C,   Colman S,   Morgan, M,   Ford A,   Greaves, M.

Blood
Volume: 116, Pages: 28.

Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk

Amy L. Sherborne,  Fay J. Hosking,  Rashmi B. Prasad,  Rajiv Kumar,  Rolf Koehler,  Jayaram Vijayakrishnan,  Elli Papaemmanuil,  Claus R. Bartram,  Martin Stanulla,  Martin Schrappe,  Andreas Gast,  Sara E. Dobbins,  Yussanne Ma,  Eamonn Sheridan,  Malcolm Taylor,  Sally E. Kinsey,  Tracey Lightfoot,  Eve Roman,  Julie A. E. Irving,  James M. Allan,  Anthony V. Moorman,  Christine J. Harrison,  Ian P. Tomlinson,  Sue Richards,  Martin Zimmermann,  Csaba Szalai,  Agnes F. Semsei,  Daniel J. Erdelyi,  Maja Krajinovic,  Daniel Sinnett,  Jasmine Healy,  Anna Gonzalez Neira,  Norihiko Kawamata,  Seishi Ogawa,  H. Phillip Koeffler,  Kari Hemminki,  Mel Greaves,  Richard S. Houlston.

Nature Genetics
Volume: 42, Issue: 6, Pages: 492-494.

A study of aberrant DNA methylation in refractory and relapsed paediatric Acute Lymphoblastic Leukaemia

Kapatai, G,   Nyangoma S,   Kearns, P.

Blood
Volume: 114, Pages: 3456.

What Is the Initiating Mechanism of iAMP21 in Childhood B Cell Precursor ALL?.

Vikki Rand,  Helen Parker,  Lisa J Russell,  Julie Irving,  Lisa Jones,  Dino Masic,  Lynne Minto,  Heather Morrison,  Hazel Robinson,  Claire Schwab,  Paul Sinclair,  Anthony V Moorman,  Jonathan C Strefford,  Christine J Harrison.

ASH Annual Meeting Abstracts
Volume: 114, Issue: 22, Pages: 581.

Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia

Elli Papaemmanuil,  Fay J. Hosking,  Jayaram Vijayakrishnan,  Amy Price,  Bianca Olver,  Eammon Sheridan,  Sally E. Kinsey,  Tracy Lightfoot,  Eve Roman,  Julie A. E. Irving,  James M. Allan,  Ian P. Tomlinson,  Malcolm Taylor,  Mel Greaves,  Richard S. Houlston.

Nature Genetics
Volume: 41, Issue: 9, Pages: 1006-1010.

Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000

Y. Ravindranath,  M. Chang,  C. P. Steuber,  D. Becton,  G. Dahl,  C. Civin,  B. Camitta,  A. Carroll,  S. C. Raimondi,  H. J. Weinstein.

Leukemia
Volume: 19, Issue: 12, Pages: 2101-2116.

Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial

C. D. Mitchell,  S. M. Richards,  S. E. Kinsey,  J. Lilleyman,  A. Vora,  T. O. B. Eden,  the Medical Research Council Childhood Leukaemia Working Party.

British Journal of Haematology
Volume: 129, Issue: 6, Pages: 734-745.

Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemia | Leukemia

No authors found.

Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemia | Leukemia

No authors found.